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一名年轻女性眼眶原发性间叶性软骨肉瘤：影像学和组织病理学特征

Primary mesenchymal chondrosarcoma of the orbit in a young female: imaging and histopathological features.

作者信息

D'Alì Lorenzo, Tulisso Angelica, Mariuzzi Laura

机构信息

Department of Pathology, Ospedale Universitario Santa Maria Della Misericordia, Udine, Italy.

出版信息

J Surg Case Rep. 2020 Mar 28;2020(3):rjaa037. doi: 10.1093/jscr/rjaa037. eCollection 2020 Mar.

DOI:10.1093/jscr/rjaa037
PMID:32257101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7103418/
Abstract

Mesenchymal chondrosarcoma (MCS) is a rare high-grade sarcoma of bone and soft tissue with highly aggressive behavior and a peak incidence in the second and third decades. We report a case of primary orbital MCS in a 30 year-old female, with radiological and clinicopathological features. Orbital MCS is an entity that should be considered in the differential diagnosis of calcified orbital lesions.

摘要

间叶性软骨肉瘤（MCS）是一种罕见的骨与软组织高级别肉瘤，具有高度侵袭性，发病高峰在第二个和第三个十年。我们报告一例30岁女性原发性眼眶MCS病例，具有影像学和临床病理特征。眼眶MCS是一种在钙化性眼眶病变的鉴别诊断中应予以考虑的疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/67dc9f66ac41/rjaa037f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/b175ec32dcc4/rjaa037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/16bbb1d3a9a1/rjaa037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/f35336b02174/rjaa037f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/270347c9bc99/rjaa037f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/88bc95f05198/rjaa037f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/67dc9f66ac41/rjaa037f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/b175ec32dcc4/rjaa037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/16bbb1d3a9a1/rjaa037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/f35336b02174/rjaa037f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/270347c9bc99/rjaa037f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/88bc95f05198/rjaa037f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b45f/7103418/67dc9f66ac41/rjaa037f6.jpg

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本文引用的文献

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Br J Radiol. 2018 Oct;91(1090):20170579. doi: 10.1259/bjr.20170579. Epub 2018 Jul 25.
2
Mesenchymal Chondrosarcoma of the Orbit Attached to the Optic Nerve.附着于视神经的眼眶间叶性软骨肉瘤
J Craniofac Surg. 2018 Sep;29(6):e591-e594. doi: 10.1097/SCS.0000000000004635.
3
Primary mesenchymal chondrosarcoma of the orbit: Histopathological report of 3 pediatric cases.眼眶原发性间叶性软骨肉瘤：3例儿科病例的组织病理学报告。
Saudi J Ophthalmol. 2018 Jan-Mar;32(1):69-74. doi: 10.1016/j.sjopt.2018.02.016. Epub 2018 Mar 8.
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Mesenchymal chondrosarcoma of the orbit: CT and MRI findings.眼眶间叶性软骨肉瘤：CT 和 MRI 表现。
Clin Radiol. 2012 Apr;67(4):346-51. doi: 10.1016/j.crad.2011.10.004. Epub 2011 Dec 16.
5
Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.基于全外显子组表达数据的基因组筛选，鉴定间叶性软骨肉瘤中新型、反复出现的 HEY1-NCOA2 融合。
Genes Chromosomes Cancer. 2012 Feb;51(2):127-39. doi: 10.1002/gcc.20937. Epub 2011 Oct 27.
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Mesenchymal chondrosarcoma of the orbit: a unique radiologic-pathologic correlation.眼眶间叶性软骨肉瘤：一种独特的放射学-病理学相关性
Ophthalmic Plast Reconstr Surg. 2009 May-Jun;25(3):219-22. doi: 10.1097/IOP.0b013e3181a142fc.
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Unusual benign and malignant chondroid tumors of bone. A survey of some mesenchymal cartilage tumors and malignant chondroblastic tumors, including a few multicentric ones, as well as many atypical benign chondroblastomas and chondromyxoid fibromas.骨的罕见良性和恶性软骨样肿瘤。对一些间叶性软骨肿瘤和恶性成软骨细胞瘤的调查，包括少数多中心性肿瘤，以及许多非典型良性成软骨细胞瘤和软骨黏液样纤维瘤。
Cancer. 1959 Nov-Dec;12:1142-57. doi: 10.1002/1097-0142(195911/12)12:6<1142::aid-cncr2820120610>3.0.co;2-d.
8
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.Sox9是软骨形成的主要调节因子，可将间叶性软骨肉瘤与其他小圆形蓝色细胞肿瘤区分开来。
Hum Pathol. 2003 Mar;34(3):263-9. doi: 10.1053/hupa.2003.41.