Nandy Debparna, Rajam Sruthy Manuraj, Dutta Debasree
Regenerative Biology Program, Rajiv Gandhi Centre for Biotechnology, Thycaud PO, Poojappura, Thiruvananthapuram, Kerala 695014 India.
Cell Biosci. 2020 Mar 30;10:52. doi: 10.1186/s13578-020-00415-1. eCollection 2020.
Thanks to the advancement in science and technology and a significant number of cancer research programs being carried out throughout the world, the prevention, prognosis and treatment of breast cancer are improving with a positive and steady pace. However, a stern thoughtful attention is required for the metastatic breast cancer cases-the deadliest of all types of breast cancer, with a character of relapse even when treated. In an effort to explore the less travelled avenues, we summarize here studies underlying the aspects of histone epigenetics in breast cancer metastasis. Authoritative reviews on breast cancer epigenetics are already available; however, there is an urgent need to focus on the epigenetics involved in metastatic character of this cancer. Here we put forward a comprehensive review on how different layers of histone epigenetics comprising of histone chaperones, histone variants and histone modifications interplay to create breast cancer metastasis landscape. Finally, we propose a hypothesis of integrating histone-epigenetic factors as biomarkers that encompass different breast cancer subtypes and hence could be exploited as a target of larger population.
得益于科技的进步以及全球范围内大量开展的癌症研究项目，乳腺癌的预防、预后和治疗正以积极且稳定的步伐不断改善。然而，对于转移性乳腺癌病例——所有类型乳腺癌中最致命的一种，即使经过治疗仍有复发的特性——需要给予严厉而审慎的关注。为了探索较少有人涉足的领域，我们在此总结了乳腺癌转移中组蛋白表观遗传学方面的相关研究。关于乳腺癌表观遗传学已有权威综述；然而，迫切需要关注与这种癌症转移特性相关的表观遗传学。在此，我们对由组蛋白伴侣、组蛋白变体和组蛋白修饰组成的不同层次的组蛋白表观遗传学如何相互作用以构建乳腺癌转移格局进行全面综述。最后，我们提出一个将组蛋白表观遗传因子整合为生物标志物的假说，该假说涵盖不同的乳腺癌亚型，因此可作为更广泛人群的靶点加以利用。
