Blumenthal N M
Department of Periodontics, University of Illinois, College of Dentistry, Chicago.
J Periodontol. 1988 Dec;59(12):830-6. doi: 10.1902/jop.1988.59.12.830.
The aim of the present investigation was to evaluate the effectiveness of collagen membrane placement in excluding gingival epithelium and connective tissue cells and guiding new attachment in surgical treatment of created defects in dogs. Sixty defects were chosen at random and balanced in regard to receiving the following treatments: 1) untreated control, 2) debrided control, and 3) collagen membrane placement over the defect (along the root surface and under the replaced flap). Histologic and histometric evaluation at 2-12 weeks post-operatively determined the healing responses of each treatment modality. Epithelium migration with no new attachment occurred in the untreated and debrided areas. Collagen membrane placement was effective in inhibiting epithelial migration and encouraging formation of new connective tissue attachment to root surface previously altered by plaque.
本研究的目的是评估在犬类手术治疗所造成的缺损时，放置胶原膜在排除牙龈上皮和结缔组织细胞以及引导新附着方面的有效性。随机选择60个缺损，并在接受以下治疗方面进行平衡：1）未治疗的对照组，2）清创对照组，3）在缺损处（沿根面并在复位瓣下方）放置胶原膜。术后2至12周的组织学和组织计量学评估确定了每种治疗方式的愈合反应。在未治疗和清创区域发生了上皮迁移但没有新的附着。放置胶原膜在抑制上皮迁移和促进新的结缔组织附着到先前因菌斑而改变的根面方面是有效的。
