Key Laboratory of Stomatology in Hebei Province, Hospital of Stomatology Hebei Medical University, Shijiazhuang, China.
College of Stomatology, Hebei Medical University, Shijiazhuang, China.
BMC Oral Health. 2024 Sep 27;24(1):1138. doi: 10.1186/s12903-024-04909-z.
Polyetheretherketone (PEEK) is well known for its excellent physical-chemical properties and biosafety. The study aimed to open up a new method for clinical application of PEEK to reconstruct large-scale bone defects.
A bilayer scaffold for bone regeneration was prepared by combining a sulfonated PEEK barrier framework (SPEEK) with a hydrogel layer loaded with aspirin (ASA) and nano-hydroxyapatite (nHAP) by the wet-bonding of Polydopamine (PDA).
The hydrogel was successfully adhered to the surface of SPEEK, resulting in significant changes including the introduction of bioactive groups, improved hydrophilicity, and altered surface morphology. Subsequent tests confirmed that the bilayer scaffold exhibited enhanced compression resistance and mechanical compatibility with bone compared to a single hydrogel scaffold. Additionally, the bilayer scaffold showed stable and reliable bonding properties, as well as excellent biosafety verified by cell proliferation and viability experiments using mouse embryo osteoblast precursor (MC3T3-E1) cells.
The bilayer bone regeneration scaffold prepared in this study showed promising potential in clinical application for bone regeneration.
聚醚醚酮（PEEK）以其优异的物理化学性能和生物安全性而闻名。本研究旨在为 PEEK 的临床应用开辟新途径，以重建大规模骨缺损。
通过聚多巴胺（PDA）的湿键合，将载有阿司匹林（ASA）和纳米羟基磷灰石（nHAP）的水凝胶层与磺化 PEEK 阻隔骨架（SPEEK）结合，制备用于骨再生的双层支架。
水凝胶成功地附着在 SPEEK 表面，导致生物活性基团的引入、亲水性的提高和表面形貌的改变等显著变化。随后的测试证实，与单一水凝胶支架相比，双层支架具有更高的抗压强度和与骨骼更好的机械相容性。此外，双层支架具有稳定可靠的键合性能，并且通过使用小鼠胚胎成骨前体细胞（MC3T3-E1）细胞进行细胞增殖和活力实验验证了其具有良好的生物安全性。
本研究制备的双层骨再生支架在骨再生的临床应用中具有广阔的应用前景。
