Intriago M, Maldonado G, Guerrero R, Messina O D, Rios C
Universidad Espíritu Santo, Km 2.5 Vía La Puntilla, Samborondón, Guayaquil, Ecuador.
General Hospital, Pi y Margall 750, C1155AHD CABA, Buenos Aires, Argentina.
J Aging Res. 2020 Mar 17;2020:1072675. doi: 10.1155/2020/1072675. eCollection 2020.
To study the association between osteoporosis and sarcopenia and determine the prevalence of osteosarcopenia in patients who attended a rheumatology center in Ecuador.
A cross-sectional study was conducted in a population of patients who had a densitometric study. The diagnosis of sarcopenia was determined by the DXA standard gold test, screening, and conventional methods (bioimpedance, anthropometric measurements, SARC-F, muscle function, and gait test).
A total of 92 patients were studied. The median age was 66 ± 10, 90% females. Using the criteria of SMI, 65% had sarcopenia of which 9% had only sarcopenia and 56% had osteosarcopenia; 22% had only osteopenia/osteoporosis; and 13% none of these conditions. The prevalence of sarcopenia according to handgrip strength was 60%, gait speed 45%, and SARC-F score 40%. The prevalence of osteosarcopenia according to handgrip strength was 51%, gait speed 34%, and SARC-F score 32%. Osteoporosis was associated with a higher prevalence of sarcopenia using the criteria of SMI since 40% had sarcopenia in the normal DXA group, 64% in the osteopenia group, and 76% in the osteoporosis group (=0.017). Of the women, 69% had sarcopenia compared to 33% of the men (=0.034). The BMI was lower in the group with sarcopenia (25.1 ± 4.1 kg/m) compared to the group without sarcopenia (29.4 ± 4.1 kg/m, < 0.001). Patients with osteosarcopenia and sarcopenia had lower BMI, handgrip strength, ASM, SMI, and total-body skeletal muscle mass than those with osteopenia/osteoporosis or normal patients.
65% of the studied population had sarcopenia. It is clear that the prevalence of sarcopenia is higher in patients with greater loss of bone mass. Identifying pathways that affect both bone and muscle could facilitate the development of treatments that simultaneously improve osteoporosis and sarcopenia.
研究骨质疏松症与肌肉减少症之间的关联，并确定厄瓜多尔一家风湿病中心患者中骨肌减少症的患病率。
对进行了骨密度测量研究的患者群体开展一项横断面研究。肌肉减少症的诊断通过双能X线吸收法（DXA）标准金标准测试、筛查及传统方法（生物电阻抗、人体测量、SARC-F、肌肉功能和步态测试）来确定。
共研究了92例患者。中位年龄为66±10岁，90%为女性。采用肌肉量指数（SMI）标准，65%的患者存在肌肉减少症，其中9%仅患有肌肉减少症，56%患有骨肌减少症；22%仅患有骨质减少/骨质疏松症；13%无上述任何情况。根据握力评估的肌肉减少症患病率为60%，步态速度评估为45%，SARC-F评分评估为40%。根据握力评估的骨肌减少症患病率为51%，步态速度评估为34%，SARC-F评分评估为32%。采用SMI标准时，骨质疏松症与更高的肌肉减少症患病率相关，因为正常DXA组中40%的患者患有肌肉减少症，骨质减少组中为64%，骨质疏松组中为76%（P = 0.017）。女性中69%患有肌肉减少症，而男性中这一比例为33%（P = 0.034）。与无肌肉减少症的组相比，有肌肉减少症的组体重指数（BMI）更低（25.1±4.1kg/m²）（P < 0.001）。与患有骨质减少/骨质疏松症的患者或正常患者相比，患有骨肌减少症和肌肉减少症的患者BMI、握力、去脂体重、SMI和全身骨骼肌质量更低。
65%的研究人群患有肌肉减少症。显然，骨量流失更多的患者中肌肉减少症的患病率更高。确定影响骨骼和肌肉的途径可能有助于开发同时改善骨质疏松症和肌肉减少症的治疗方法。
