Gabat Julie Anne L, Faltado Antonio L, Sedurante Myrna B, Tee Michael L
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, the Philippines.
Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, the Philippines.
Osteoporos Sarcopenia. 2018 Sep;4(3):109-113. doi: 10.1016/j.afos.2018.08.001. Epub 2018 Sep 13.
Studies on the association of obesity and sarcopenia are conflicting. Some studies showed that obesity is associated with muscle loss and frailty while others showed that lower body mass index (BMI) is associated with increased sarcopenia. To date, there is paucity of data on sarcopenia and obesity among Filipinos. This study aims to determine the association of obesity and sarcopenia among Filipinos.
This is a cross sectional analytic study comparing sarcopenic versus nonsarcopenic in terms of obesity as measured by BMI and waist circumference (WC). Filipinos older than 40 years were included. Obesity was defined using the World Health Organization (WHO) cutoff for BMI and WC. Sarcopenia was defined as low muscle mass and low muscle strength or physical performance. Population-specific cutoff points were used to define low muscle mass, strength, and performance.
A total of 164 participants were included. The mean age is 60.33 years. Ten (6.1%) were sarcopenic and 4 (40%) of them were obese. Regression analysis showed that obesity is not significantly associated with increased sarcopenia (incidence risk ratio [IRR], 14.62; 95% confidence interval [CI], 0.96-221.92; P = 0.05). However, age (IRR, 1.15; 95% CI, 1.09-1.21; P ≤ 0.01), WC (IRR, 0.92; 95% CI, 0.85-0.99; P = 0.02), smoking (IRR, 3.17; 95% CI, 1.11-9.03; P = 0.03), and alcoholic beverage drinking (IRR, 3.71; 95% CI, 1.26-10.89; P = 0.02) were found to be significant predictors of sarcopenia.
There is no statistically significant association between obesity and increased risk of sarcopenia among participants, however, older age, smaller WC, smoking, and alcoholic beverage drinking were significant predictors of sarcopenia.
关于肥胖与肌肉减少症之间关联的研究结果相互矛盾。一些研究表明，肥胖与肌肉流失和身体虚弱有关，而另一些研究则表明，较低的体重指数（BMI）与肌肉减少症增加有关。迄今为止，菲律宾人肌肉减少症和肥胖症的数据匮乏。本研究旨在确定菲律宾人肥胖与肌肉减少症之间的关联。
这是一项横断面分析研究，比较了根据BMI和腰围（WC）衡量的肥胖情况下的肌肉减少症患者与非肌肉减少症患者。纳入年龄超过40岁的菲律宾人。肥胖采用世界卫生组织（WHO）的BMI和WC临界值来定义。肌肉减少症定义为低肌肉量以及低肌肉力量或身体机能。使用特定人群的临界值来定义低肌肉量、力量和机能。
共纳入164名参与者。平均年龄为60.33岁。10人（6.1%）患有肌肉减少症，其中4人（40%）肥胖。回归分析表明，肥胖与肌肉减少症增加无显著关联（发病风险比[IRR]，14.62；95%置信区间[CI]，0.96 - 221.92；P = 0.05）。然而，年龄（IRR，1.15；95% CI，1.09 - 1.21；P≤0.01）、WC（IRR，0.92；95% CI，0.85 - 0.99；P = 0.02）、吸烟（IRR，3.17；95% CI，1.11 - 9.03；P = 0.03）和饮用酒精饮料（IRR，3.71；95% CI，1.26 - 10.89；P = 0.02）被发现是肌肉减少症的显著预测因素。
参与者中肥胖与肌肉减少症风险增加之间无统计学显著关联，然而，年龄较大、WC较小、吸烟和饮用酒精饮料是肌肉减少症的显著预测因素。
