甲状腺朗格汉斯细胞组织细胞增多症导致播散型的诊断
Langerhans Cell Histiocytosis of the Thyroid Leading to the Diagnosis of a Disseminated Form.
作者信息
Ben Nacef Ibtissem, Mekni Sabrine, Mhedhebi Chedi, Riahi Ines, Rojbi Imen, Nadia Mchirgui, Khiari Karima
机构信息
Department of Endocrinology, Charles Nicolle Hospital, Tunis, Tunisia.
Department of Otorhinolaryngology-Head and Neck Surgery, Charles Nicolle Hospital, Tunis, Tunisia.
出版信息
Case Rep Endocrinol. 2020 Mar 17;2020:6284764. doi: 10.1155/2020/6284764. eCollection 2020.
Langerhans cell histiocytosis (LCH) is a rare sporadic proliferative disorder of Langerhans cells. LCH rarely involves the thyroid gland. We report herein a case of a disseminated chronic form of LCH with a diagnosis established by histological examination of the thyroid gland. It is about a 37-year-old female who underwent total thyroidectomy for a thyroid nodule of the right lobe. Histological study showed a granulomatous thyroiditis, and the immunohistochemistry study revealed a strong positivity of histiocytes for the CD1 antigen and for the S100 protein. The incidence of LCH involving the thyroid gland, either as an isolated lesion or as a part of multisystemic disease, is extremely rare.
朗格汉斯细胞组织细胞增多症（LCH）是一种罕见的朗格汉斯细胞散发性增殖性疾病。LCH很少累及甲状腺。我们在此报告一例播散性慢性LCH病例，其诊断通过甲状腺组织学检查确定。患者为一名37岁女性，因右叶甲状腺结节接受了全甲状腺切除术。组织学研究显示为肉芽肿性甲状腺炎，免疫组织化学研究显示组织细胞对CD1抗原和S100蛋白呈强阳性。LCH累及甲状腺，无论是作为孤立病变还是作为多系统疾病的一部分，其发生率都极其罕见。
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