Neonatal Intensive Care Unit (NICU), Women's Wellness and Research Center (WWRC), Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar.
Department of Medical Education, Hamad Medical Corporation (HMC), P.O. Box 3050, Doha, Qatar.
Biomed Res Int. 2020 Mar 12;2020:7953289. doi: 10.1155/2020/7953289. eCollection 2020.
Preeclampsia is a major cause of pregnancy-related maternal, fetal, and neonatal morbidities and mortalities. We aimed to review the effect of maternal preeclampsia on the hematological profile of newborns in the Qatari population.
In this case-control study, we reviewed data and complete blood count results of neonates born to Qatari women diagnosed of preeclampsia in 2017 in comparison with data of a control group. Statistical analysis was done using unpaired t-test, chi-square test, and logistic regression analysis.
A total of 108 neonates of women with preeclampsia and 103 neonates of healthy normotensive women were recruited. The mean weight, length, head circumference, placental weight, and gestational age were significantly lower ( < 0.05) in neonates born to women with preeclampsia. Only 13% of babies born to women with preeclampsia developed neonatal thrombocytopenia which is significantly higher compared to only 2% in the control group (chi-square = 9.14; < 0.05) in neonates born to women with preeclampsia. No significant difference ( > 0.05) was noted between the two groups regarding the white blood cells (WBC) or the absolute neutrophilic count (ANC). Multivariate logistic regression showed that the gestational age, birth weight, length, and ANC had significant association with preeclampsia ( < 0.05).
We found that there was a positive association between preeclampsia and neonatal thrombocytopenia in the Qatari population. Prematurity, placenta insufficiency, fetal growth restriction, and need for neonatal resuscitation were significantly higher in babies born to women with preeclampsia. We recommend that hematological parameters of neonates of those women should be properly monitored to reduce the chances of developing complications.
子痫前期是导致妊娠相关母体、胎儿和新生儿发病率和死亡率的主要原因。我们旨在评估卡塔尔人群中母亲子痫前期对新生儿血液学特征的影响。
在这项病例对照研究中，我们回顾了 2017 年诊断为子痫前期的卡塔尔妇女所生新生儿的数据和全血细胞计数结果，并与对照组数据进行了比较。使用配对 t 检验、卡方检验和逻辑回归分析进行了统计学分析。
共纳入了 108 例子痫前期妇女所生新生儿和 103 例健康正常血压妇女所生新生儿。子痫前期妇女所生新生儿的平均体重、身长、头围、胎盘重量和胎龄明显较低（<0.05）。仅 13%的子痫前期妇女所生婴儿发生新生儿血小板减少症，明显高于对照组的 2%（卡方=9.14；<0.05）。子痫前期妇女所生新生儿的白细胞（WBC）或绝对中性粒细胞计数（ANC）两组间无显著差异（>0.05）。多变量逻辑回归显示，胎龄、出生体重、身长和 ANC 与子痫前期有显著关联（<0.05）。
我们发现，在卡塔尔人群中，子痫前期与新生儿血小板减少症之间存在正相关关系。子痫前期妇女所生婴儿的早产、胎盘功能不全、胎儿生长受限和新生儿复苏的需求明显更高。我们建议，应对这些妇女的新生儿的血液学参数进行适当监测，以降低发生并发症的几率。
