Department of Dermatology, University of Rzeszow, Rzeszów, Poland.
Students' Scientific Circle of Experimental Dermatology, Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wrocław, Poland.
Biomed Res Int. 2020 Mar 13;2020:9186274. doi: 10.1155/2020/9186274. eCollection 2020.
The aim of the study was to evaluate QoL in patients suffering from morphea. . Sixty-five patients with morphea were recruited into this cross-sectional, prospective parallel study. QoL among adult patients was assessed with the Dermatology Life Quality Index (DLQI) and Euro-QoL-5D questionnaire; patients aged <17 years used the Children's Dermatology Life Quality Index (CDLQI). The severity of morphea was assessed using the Localized Scleroderma Cutaneous Assessment Tool. The results of QoL and its association with disease severity were compared between patients with various morphea subtypes.
The mean DLQI scoring was 3.8 ± 4.1 points and the CDLQI was 2.3 ± 3.0. The mean value of Visual Analogue Scale thermometer (EQ VAS) was 66.9 ± 17.5 points. The disease activity of morphea based on mLoSSI correlated significantly with QoL impairment according to the DLQI ( = 0.41, = 0.001). No significant correlation was observed between morphea-induced damage and QoL ( = 0.99).
Evaluation of QoL in patients with morphea is still challenging due to lack of good assessment tools dedicated specifically for morphea patients. In general, QoL in morphea patients is significantly correlated with the disease activity, but not with disease-induced skin damage.
本研究旨在评估硬斑病患者的生活质量。方法：采用横断面前瞻性平行研究，共纳入 65 例硬斑病患者。采用皮肤病生活质量指数（DLQI）和欧洲五维健康量表（EQ-5D）评估成年患者的生活质量，年龄<17 岁的患者采用儿童皮肤病生活质量指数（CDLQI）进行评估。采用局限性硬皮病皮肤评估工具（LoSSI）评估硬斑病的严重程度。比较不同硬斑病亚型患者的生活质量及其与疾病严重程度的相关性。结果：DLQI 平均得分为 3.8±4.1 分，CDLQI 为 2.3±3.0 分。视觉模拟评分量表（EQ VAS）的平均分值为 66.9±17.5 分。基于 mLoSSI 的硬斑病活动度与 DLQI 评分的生活质量受损显著相关（ = 0.41， = 0.001）。硬斑病引起的皮肤损伤与生活质量之间无显著相关性（ = 0.99）。结论：由于缺乏专门针对硬斑病患者的评估工具，评估硬斑病患者的生活质量仍然具有挑战性。一般来说，硬斑病患者的生活质量与疾病活动度显著相关，但与疾病引起的皮肤损伤无关。
