Szczepanik-Kułak Paulina, Michalska-Jakubus Małgorzata, Krasowska Dorota
Chair and Department of Dermatology, Venerology and Paediatric Dermatology, Medical University of Lublin, 20-081 Lublin, Poland.
J Clin Med. 2021 Jul 30;10(15):3409. doi: 10.3390/jcm10153409.
Morphea, also known as localized scleroderma (LoS), comprises a set of autoimmune sclerotic skin diseases. It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved. Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' quality of life. Therapy for LoS is often unsatisfactory with numerous treatments that have only limited effectiveness or considerable side effects. Due to the advances in the application of lasers and their possible beneficial effects, the aim of this study is to review the reported usage of laser in morphea. We present a systematic review of available literature, performed with MEDLINE, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases. We identified a total of twenty relevant studies (MEDLINE = 10, Cinahl = 1, Central = 0, Scopus = 2, Web of Science = 5, Google Scholar = 2) using laser therapy for LoS. Eight studies were focused on the use of PDL, six on fractional lasers (CO and Er:YAG), four on excimer, and two on either alexandrite or Nd:YAG.
硬斑病，也称为局限性硬皮病（LoS），是一组自身免疫性硬化性皮肤病。其特征为皮肤炎症以及局限性增厚和硬结；然而，在某些情况下，更深层的组织也可能受累。尽管硬斑病不被认为是危及生命的疾病，但明显的外貌毁损、功能或心理社会障碍会影响患者生活质量的多个方面。LoS的治疗往往不尽人意，众多治疗方法效果有限或有相当大的副作用。由于激光应用的进展及其可能的有益效果，本研究的目的是回顾激光在硬斑病中的应用报道。我们对通过MEDLINE、Cinahl、Central、Scopus、科学网和谷歌学术数据库进行的现有文献进行了系统综述。我们共确定了20项使用激光疗法治疗LoS的相关研究（MEDLINE = 10、Cinahl = 1、Central = 0、Scopus = 2、科学网 = 5、谷歌学术 = 2）。8项研究聚焦于脉冲染料激光（PDL）的使用，6项聚焦于分数激光（CO和铒：钇铝石榴石），4项聚焦于准分子激光，2项聚焦于翠绿宝石激光或钕：钇铝石榴石激光。
