Sadaghiani Safa, Fallahi Soghra, Heshmati Hossein, Teshnizi Saeed Hosseini, Chaijan Hooshang Abedini, Ebrahimi Fahimeh Farzad Amir, Khorrami Farhad, Poorrezaeian Mina, Alizadeh Faezeh
Department of Nursing, Faculty of Nursing and Midwifery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
AIMS Public Health. 2020 Feb 11;7(1):92-99. doi: 10.3934/publichealth.2020009. eCollection 2020.
Naturally, in human body, there is a balance between free radicals and the antioxidant system. Yet, cigarette consumption in smokers increases free radicals and decreases antioxidants. A vast body of research showed that the ROS level of seminal fluid is reduced using oral antioxidant complements through enhancing the clearing capacity of free radicals. Thus, the present research aimed to explore the effect of vitamin complement consumption on changing male infertility indices among smokers.
In the present randomized clinical trial which was single-blinded, 50 infertile oligospermic and asthenospermic men participated. They were selected in a randomized convenient sampling method. Before the study began, a semen sample was taken from all participants for analysis. Subsequently, the patients received 30 mg of Q10 coenzyme, 8 mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid for a whole duration of 3 months on a daily basis (once a day) and 200 mg of selenium every other day after lunch. A second sample of seminal fluid was taken from patients and semen parameters were compared between the pre- and post-test. The relevant statistical analyses were conducted in SPSS.23.
A comparison of pre-test and post-test results revealed that all sperm parameters including the volume, morphology, motion, count and progressive motility were significantly increased after the intervention (p ≥ 005). Moreover, a statistically significant improvement was observed in the pH and concentration of seminal fluid.
The present research showed that consuming vitamin complements (30 mg of Q10, mg of zinc, 100 mg of vitamin C, 12 mg of vitamin E, 400 mg of folic acid) once a day as well as 200 mg of selenium every other day can effectively improve the qualitative parameters (pH and concentration) and quantitative parameters (volume, motion, morphology, count and progressive motility) in infertile male smokers.
在人体中，自由基与抗氧化系统之间自然存在平衡。然而，吸烟者吸烟会增加自由基并减少抗氧化剂。大量研究表明，通过增强自由基清除能力，口服抗氧化剂补充剂可降低精液中的活性氧水平。因此，本研究旨在探讨服用维生素补充剂对改变吸烟者男性不育指标的影响。
在本单盲随机临床试验中，50名不育的少精子症和弱精子症男性参与。他们采用随机便利抽样法选取。在研究开始前，从所有参与者采集精液样本进行分析。随后，患者每天（每天一次）服用30毫克辅酶Q10、8毫克锌、100毫克维生素C、12毫克维生素E、400毫克叶酸，持续3个月，并且每隔一天午餐后服用200毫克硒。从患者采集第二份精液样本，并比较测试前后的精液参数。在SPSS.23中进行相关统计分析。
测试前和测试后结果的比较显示，干预后所有精子参数，包括体积、形态、活力、数量和前向运动能力均显著增加（p≥0.05）。此外，精液的pH值和浓度有统计学意义的改善。
本研究表明，每天服用维生素补充剂（30毫克辅酶Q10、8毫克锌、100毫克维生素C、12毫克维生素E、400毫克叶酸）以及每隔一天服用200毫克硒可有效改善不育男性吸烟者的质量参数（pH值和浓度）和数量参数（体积、活力、形态、数量和前向运动能力）。
