Jibira Yakubu, Boakye-Gyasi Eric, Kofi Mensah Abotsi Wonder, Amponsah Isaac Kingsley, Adongo Donatus Wewura, Woode Eric
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Adv Pharmacol Pharm Sci. 2020 Feb 12;2020:7232579. doi: 10.1155/2020/7232579. eCollection 2020.
. The stem bark of the savanna tree (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases.
This study seeks to investigate the possible antiallodynic and antihyperalgesic effects of the hydroethanolic stem bark extract of in a vincristine-induced peripheral neuropathy model in rats. . 0.1 mg kg vincristine was administered intraperitoneally for 5 days followed by 2 days break and continued for another 5 days to establish peripheral neuropathy in Sprague Dawley rats. Effects of (Hook) (family: Leguminosae) is used in the Ghanaian traditional medicine for the management of various pain-related diseases. ) and pregabalin (10-100 mg kg, ) were assessed on tactile, intermediate, mechanical, cold, and hot allodynia as well as in the Randall-Sellito test. Moreover, the levels of total proteins, malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in sciatic nerve tissue homogenates were assayed.
BAE (50-1000 mg kg .) showed significant antiallodynic and antihyperalgesic effects similar to pregabalin by increasing paw withdrawal latency and paw withdrawal threshold in all the behavioral tests used. Also, the extract decreased the levels of MDA (a lipid peroxidation product) as well as MPO and caused a significant increase in endogenous antioxidants (GSH) and antioxidant enzymes (SOD and CAT) in tissue homogenates of treated rats.
Results from this study indicate that the hydroethanolic stem bark extract of exhibits antiallodynic and antihyperalgesic effects in vincristine-induced peripheral neuropathy in rats. in a vincristine-induced peripheral neuropathy model in rats.
热带草原树木（胡克）（豆科）的茎皮在加纳传统医学中用于治疗各种与疼痛相关的疾病。
本研究旨在探讨该植物茎皮水乙醇提取物在长春新碱诱导的大鼠周围神经病变模型中可能的抗痛觉过敏和抗痛觉超敏作用。给Sprague Dawley大鼠腹腔注射0.1mg/kg长春新碱，持续5天，随后休息2天，再继续给药5天以建立周围神经病变。评估该植物（胡克）（豆科）提取物（50 - 1000mg/kg，口服）和普瑞巴林（10 - 100mg/kg，口服）对触觉、中度、机械性、冷和热痛觉过敏的影响，以及在Randall - Sellito试验中的作用。此外，还测定了坐骨神经组织匀浆中总蛋白、丙二醛（MDA）、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的水平。
该植物茎皮提取物（50 - 1000mg/kg，口服）在所有使用的行为测试中，通过增加爪退缩潜伏期和爪退缩阈值，显示出与普瑞巴林相似的显著抗痛觉过敏和抗痛觉超敏作用。此外，该提取物降低了MDA（一种脂质过氧化产物）以及MPO的水平，并使处理大鼠组织匀浆中的内源性抗氧化剂（GSH）和抗氧化酶（SOD和CAT）显著增加。
本研究结果表明，该植物茎皮水乙醇提取物在长春新碱诱导的大鼠周围神经病变中具有抗痛觉过敏和抗痛觉超敏作用。在大鼠长春新碱诱导的周围神经病变模型中。
