Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Hospital of the Universities of Giessen and Marburg UKGM, Justus Liebig University Giessen, Giessen, Hessen Germany.
Am J Med. 2020 Jul;133(7):783-788. doi: 10.1016/j.amjmed.2020.03.008. Epub 2020 Apr 5.
Multiple sclerosis (MS) is a common, severe neurological disease that affects millions of people worldwide. Nevertheless, the actual cause of MS remains unknown. Smoking has been studied with respect to MS development and progression. The objectives of this review were to examine the relationship between smoking and MS and to understand the possible molecular mechanisms underlying the association. PubMed was searched for articles related to the study topic published between 2012 and 2020 using the search terms "multiple sclerosis," "smoking," "risk factors," "cigarettes," and "molecular mechanisms." Studies show a significant relationship between smoking and the risk of MS. Furthermore, smoking has been linked to the progression of MS at the patient and population levels. However, the underlying mechanism remains to be explored in further studies; researchers still disagree on how the relationship between smoking and MS arises in different populations. Evidence from randomized controlled trials, systematic reviews, and epidemiological studies shows that smokers have a higher risk of developing MS and experiencing related adverse symptoms and complications.
多发性硬化症（MS）是一种常见的严重神经系统疾病，影响着全球数百万人。然而，MS 的实际病因仍不清楚。吸烟与 MS 的发生和发展有关。本综述的目的是研究吸烟与 MS 之间的关系，并了解其关联的可能分子机制。使用“多发性硬化症”、“吸烟”、“危险因素”、“香烟”和“分子机制”等检索词，在 PubMed 上检索了 2012 年至 2020 年发表的与研究主题相关的文章。研究表明吸烟与 MS 风险之间存在显著关系。此外，吸烟与患者和人群水平的 MS 进展有关。然而，其潜在机制仍需在进一步的研究中探讨；研究人员仍然不同意吸烟与 MS 之间的关系在不同人群中是如何产生的。来自随机对照试验、系统评价和流行病学研究的证据表明，吸烟者患 MS 以及出现相关不良症状和并发症的风险更高。
