Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Global Health Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Front Public Health. 2022 Sep 6;10:973753. doi: 10.3389/fpubh.2022.973753. eCollection 2022.
Few studies have reported the association of early life exposure to famine with the risk of heart failure. The current study aimed to investigate whether exposure to famine in early life is associated with a higher risk of hospitalization for heart failure in adulthood.
We used data from participants included in the sub-cohort of the China Patient-centered Evaluative Assessment of Cardiac Events Million Persons Project in Guangdong Province. Specific years of birth were used to define the famine-exposed group (born during the famine of 1959-1962), the pre-famine group (born before the famine [1954-1957], and the post-famine group (born after the famine [1964-1967]). Multivariable-adjusted generalized linear models were used to examine the associations of early life famine exposure with the risk of hospitalization for heart failure.
A total of 36,212 participants were enrolled in this analysis with a median age of 57.4 years and 37.5% of them were men. Compared with the post-famine group, famine births and pre-famine births were associated with increased risk of heart failure (OR: 1.96 [1.56-2.48] and OR: 1.62 [1.07-2.47], respectively). When compared with the age-balanced non-exposed group, the famine-exposed group was also significantly associated with increased risk of heart failure (OR: 1.32 [1.11-1.57]). The associations were stronger in participants with better economic status and in participants with hypertension, diabetes, and dyslipidemia (P for interaction < 0.05).
Early life exposure to the Chinese famine is associated with an elevated risk of hospitalization for heart failure in adulthood.
鲜有研究报道生命早期暴露于饥荒与心力衰竭风险之间的关系。本研究旨在探究生命早期暴露于饥荒是否与成年后心力衰竭住院风险升高相关。
我们使用了广东省中国心血管事件评估患者队列研究的亚队列参与者的数据。具体的出生年份用于定义暴露于饥荒组（1959-1962 年饥荒期间出生）、饥荒前组（1954-1957 年饥荒前出生）和饥荒后组（1964-1967 年饥荒后出生）。采用多变量调整的广义线性模型来检验生命早期饥荒暴露与心力衰竭住院风险之间的关联。
共纳入 36212 名参与者，中位年龄为 57.4 岁，其中 37.5%为男性。与饥荒后组相比，饥荒出生和饥荒前出生与心力衰竭风险升高相关（OR：1.96 [1.56-2.48]和 OR：1.62 [1.07-2.47]）。与年龄匹配的非暴露组相比，暴露于饥荒组也与心力衰竭风险升高显著相关（OR：1.32 [1.11-1.57]）。在经济状况较好的参与者以及患有高血压、糖尿病和血脂异常的参与者中，这种关联更为显著（P 交互 < 0.05）。
生命早期暴露于中国饥荒与成年后心力衰竭住院风险升高相关。
