Kim Hyunjin, Mun Saehun, Choi Yongdoo
Molecular Imaging & Therapy Branch, National Cancer Center, 323 Ilsan-ro, Goyang-si, Gyeonggi-do 410-769, Republic of Korea.
J Mater Chem B. 2013 Jan 28;1(4):429-431. doi: 10.1039/c2tb00287f. Epub 2012 Dec 7.
Photosensitizers conjugated with hyaluronic acid via disulfide linkers were developed for biologically activatable near-infrared fluorescence imaging and photodynamic therapy. The nanoparticles prepared from the conjugate are nonfluorescent and nonphototoxic in their native state, but become highly fluorescent and phototoxic in response to reductive agents inside cancer cells.
通过二硫键连接子与透明质酸共轭的光敏剂被开发用于生物可激活的近红外荧光成像和光动力疗法。由该共轭物制备的纳米颗粒在其天然状态下无荧光且无光毒性，但在癌细胞内对还原剂产生响应时会变得具有高荧光性和光毒性。
