Kurapati Rajendra, Raichur Ashok M
Department of Materials Engineering, Indian Institute of Science, Bangalore 560012, India.
J Mater Chem B. 2013 Jul 7;1(25):3175-3184. doi: 10.1039/c3tb20192a. Epub 2013 May 23.
Novel composite cyclodextrin (CD)-CaCO spherical porous microparticles have been synthesized through Ca-CD complex formation, which influences the crystal growth of CaCO. The CDs are entrapped and distributed uniformly in the matrix of CaCO microparticles during crystallization. The hydrophobic fluorescent molecules coumarin and Nile red (NR) are efficiently encapsulated into these composite CD-CaCO porous particles through supramolecular inclusion complexation between entrapped CDs and hydrophobic molecules. Thermogravimetric (TGA) and infrared spectroscopy (IR) analysis of composite CD-CaCO particles reveals the presence of large CDs and their strong interaction with calcium carbonate nanoparticles. The resulting composite CD-CaCO microparticles are utilized as sacrificial templates for preparation of CD-modified layer-by-layer (LbL) capsules. After dissolution of the carbonate core, CDs are retained in the interior of the capsules in a network fashion and assist in the encapsulation of hydrophobic molecules. The efficient encapsulation of the hydrophobic fluorescent dye, coumarin, was successfully demonstrated using CD-modified capsules. In vitro release of the encapsulated coumarin from the CD-CaCO and CD-modified capsules has been demonstrated.
通过钙 - 环糊精（CD）复合物的形成合成了新型复合环糊精（CD）-碳酸钙球形多孔微粒，这会影响碳酸钙的晶体生长。在结晶过程中，环糊精被困在碳酸钙微粒的基质中并均匀分布。通过包埋的环糊精与疏水分子之间的超分子包合络合作用，疏水性荧光分子香豆素和尼罗红（NR）被有效地包封到这些复合CD - 碳酸钙多孔颗粒中。复合CD - 碳酸钙颗粒的热重分析（TGA）和红外光谱（IR）分析揭示了大环糊精的存在及其与碳酸钙纳米颗粒的强相互作用。所得的复合CD - 碳酸钙微粒被用作制备CD修饰的逐层（LbL）胶囊的牺牲模板。碳酸盐核溶解后，环糊精以网络形式保留在胶囊内部，并有助于疏水分子的包封。使用CD修饰的胶囊成功证明了疏水性荧光染料香豆素的有效包封。已证明包封的香豆素从CD - 碳酸钙和CD修饰的胶囊中的体外释放。
