Malakhovskii V N, Bobyr' B A, Bokk M M, Mikhaĭlichenko P P, Sergeev A A
Kosm Biol Aviakosm Med. 1988 Jul-Aug;22(4):77-81.
Experiments were performed on 52 dogs exposed to irradiation at a dose of 5-80 Gy or injected with 0.02-0.5 mg/kg apomorphine. The apomorphine effect was also studied in 18 healthy male volunteers. Apomorphine injected to dogs reproduced to a certain extent the pattern and sequence of gastrointestinal, sensorimotor and circulatory lesions constituting the primary radiation reaction. The apomorphilne dosage ED50-ED90, in terms of vomiting, roughly corresponded to irradiation at a dose of 5-10 Gy. The basic difference was that the time of onset and duration of specific symptoms after irradiation were several times longer than after apomorphine injection. It is suggested that the common pathogenetic component in the primary reaction to irradiation and its apomorphine model is the phasic change in the activities of brain dopaminergic systems.
对52只接受5 - 80 Gy剂量照射或注射0.02 - 0.5 mg/kg阿扑吗啡的狗进行了实验。还在18名健康男性志愿者身上研究了阿扑吗啡的作用。给狗注射阿扑吗啡在一定程度上重现了构成原发性辐射反应的胃肠道、感觉运动和循环系统损伤的模式和顺序。就呕吐而言，阿扑吗啡的剂量ED50 - ED90大致相当于5 - 10 Gy剂量的照射。基本区别在于，照射后特定症状的发作时间和持续时间比注射阿扑吗啡后长几倍。有人认为，对辐射及其阿扑吗啡模型的原发性反应中共同的发病机制成分是脑多巴胺能系统活动的阶段性变化。
