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利用致孔剂沥滤和投影微立体光刻技术制备导电聚苯胺水凝胶

Fabrication of conductive polyaniline hydrogel using porogen leaching and projection microstereolithography.

作者信息

Wu Yibo, Chen Yong X, Yan Jiahan, Yang Shihao, Dong Ping, Soman Pranav

机构信息

Department of Biomedical and Chemical Engineering, Syracuse University, 900 S Crouse Ave, Syracuse, NY 13210, USA.

出版信息

J Mater Chem B. 2015 Jul 14;3(26):5352-5360. doi: 10.1039/c5tb00629e. Epub 2015 Jun 10.

Abstract

Conducting hydrogels represent a new generation of "smart" biomaterials which combine the favorable biocompatibility properties of hydrogels and electrical properties of organic conductors, and would potentially lead to the development of new biointerfaces with controllable properties. Currently, conductive hydrogels are synthesized by either adding conducting particles to, or polymerizing conducting polymer monomers within, hydrogel matrix, however challenges in processing limit their applications in functional devices. In this work, a poly(ethylene glycol) diacrylate-polyaniline (PEGda-PANI) conductive hydrogel is developed using interfacial polymerization process. In this process, aniline monomers polymerize at the organic/water interface between hexane media and hydrophilic PEGda hydrogel networks. PANI chains become hydrophilic with acid doping and migrate into aqueous phase confined within PEGda networks. The synthesized PEGda-PANI hydrogel has acceptable mechanical, electrical and biocompatible properties. Traditional fabrication methods including process-driven salt-leaching and design-driven projection stereolithography were used to develop 3D scaffolds using PEGda-PANI hydrogels. This methodology can be potentially extended to a wide variety of fabrication techniques to develop hydrogels with complex geometries and next-generation functional biointerfaces.

摘要

导电水凝胶代表了新一代的“智能”生物材料,它结合了水凝胶良好的生物相容性和有机导体的电学性质,并且有可能推动具有可控性质的新型生物界面的发展。目前,导电水凝胶是通过向水凝胶基质中添加导电颗粒或在水凝胶基质中聚合导电聚合物单体来合成的,然而加工方面的挑战限制了它们在功能器件中的应用。在这项工作中,使用界面聚合工艺开发了一种聚(乙二醇)二丙烯酸酯-聚苯胺(PEGda-PANI)导电水凝胶。在这个过程中,苯胺单体在己烷介质和亲水性PEGda水凝胶网络之间的有机/水界面处聚合。PANI链通过酸掺杂变得亲水,并迁移到PEGda网络所限制的水相中。合成的PEGda-PANI水凝胶具有可接受的机械、电学和生物相容性性质。使用传统制造方法,包括工艺驱动的盐析和设计驱动的投影立体光刻,来使用PEGda-PANI水凝胶开发3D支架。这种方法有可能扩展到各种各样的制造技术,以开发具有复杂几何形状的水凝胶和下一代功能性生物界面。

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