Cong Xiufeng, Chen Jun, Xu Ran
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Front Bioeng Biotechnol. 2022 Jun 29;10:916952. doi: 10.3389/fbioe.2022.916952. eCollection 2022.
Spatially- and/or temporally-controlled drug release has always been the pursuit of drug delivery systems (DDSs) to achieve the ideal therapeutic effect. The abnormal pathophysiological characteristics of the tumor microenvironment, including acidosis, overexpression of special enzymes, hypoxia, and high levels of ROS, GSH, and ATP, offer the possibility for the design of stimulus-responsive DDSs for controlled drug release to realize more efficient drug delivery and anti-tumor activity. With the help of these stimulus signals, responsive DDSs can realize controlled drug release more precisely within the local tumor site and decrease the injected dose and systemic toxicity. This review first describes the major pathophysiological characteristics of the tumor microenvironment, and highlights the recent cutting-edge advances in DDSs responding to the tumor pathophysiological environment for cancer therapy. Finally, the challenges and future directions of bio-responsive DDSs are discussed.
空间和/或时间控制的药物释放一直是药物递送系统（DDSs）所追求的目标，以实现理想的治疗效果。肿瘤微环境的异常病理生理特征，包括酸中毒、特殊酶的过表达、缺氧以及高水平的活性氧（ROS）、谷胱甘肽（GSH）和三磷酸腺苷（ATP），为设计用于控制药物释放的刺激响应性DDSs提供了可能性，以实现更高效的药物递送和抗肿瘤活性。借助这些刺激信号，响应性DDSs可以在局部肿瘤部位更精确地实现药物控制释放，并降低注射剂量和全身毒性。本文综述首先描述了肿瘤微环境的主要病理生理特征，并重点介绍了用于癌症治疗的响应肿瘤病理生理环境的DDSs的最新前沿进展。最后，讨论了生物响应性DDSs面临的挑战和未来发展方向。
