Bakhshi Hadi, Agarwal Seema
Macromolecular Chemistry II and Bayreuth Center for Colloids and Interfaces, University of Bayreuth, Universitätsstraße 30, 95440, Bayreuth, Germany.
J Mater Chem B. 2017 Sep 7;5(33):6827-6834. doi: 10.1039/c7tb01301a. Epub 2017 Aug 3.
Herein, we present novel hyperbranched poly(amino-ester)s functionalized with quaternary ammonium salts (QAS-HPAEs). These materials can be used as antibacterial and biodegradable additives for mixing with non-active polymers. The chemical structure and thermal properties of the HPAEs were studied. All QAS-HPAEs were stable until 192 °C, which makes their thermal blending with other polymers possible. Blending polycaprolactone (PCL) as a biodegradable polymer with QAS-HPAEs improved its surface and bulk hydrophilicity, while partially decreasing its elastic modulus and tensile strength. Mixing 10 wt% of QAS-HPAEs in PCL resulted in a film with high contact-killing activity against E. coli and B. subtilis and faster degradability in the presence and absence of esterase. The activity of esterase was inhibited in the presence of a higher content of QAS-HPAEs (20 wt%).
在此，我们展示了用季铵盐（QAS-HPAEs）功能化的新型超支化聚（氨基酯）。这些材料可用作与非活性聚合物混合的抗菌和可生物降解添加剂。研究了HPAEs的化学结构和热性能。所有QAS-HPAEs在192°C之前都是稳定的，这使得它们与其他聚合物进行热共混成为可能。将聚己内酯（PCL）作为可生物降解聚合物与QAS-HPAEs共混可改善其表面和本体亲水性，同时部分降低其弹性模量和拉伸强度。在PCL中混合10 wt%的QAS-HPAEs可得到对大肠杆菌和枯草芽孢杆菌具有高接触杀灭活性且在有和没有酯酶存在的情况下降解更快的薄膜。在较高含量的QAS-HPAEs（20 wt%）存在下，酯酶的活性受到抑制。
