Naseri Shiva, Lepry William C, Nazhat Showan N
Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada.
J Mater Chem B. 2017 Aug 21;5(31):6167-6174. doi: 10.1039/c7tb01221g. Epub 2017 Jul 27.
Bioactive glasses have long been investigated in mineralized tissue regeneration, but recently their potential applications in soft tissue repair, and in particular wound healing, have demonstrated great promise. Commonly used glasses, such as the silicate-based Bioglass® 45S5 [(46.1)SiO-(26.9)CaO-(24.4)NaO-(2.6)PO (mol%)] and borate-based 13-93B3 [(54)BO-(22)CaO-(6)NaO-(8)KO-(8)MgO-(2)PO (mol%)] have been implicated in the stages of wound healing due to their ability to release ions that can stimulate processes, such as haemostasis, antibacterial efficacy, epithelial cell migration, angiogenesis, and fibroblastic cell proliferation, amongst others. More recently, a wound dressing composed of a borate-based glass received regulatory approval for use in the treatment of acute and chronic wounds. However, to date, there are no comprehensive reports on their specific mechanism of action in accelerating the wound healing processes. In this highlight, we will provide a brief overview of the wound healing stages, review the bioactive glass formulations that have been investigated for potential applications in wound healing and attempt to summarize the consensus on why these glasses may be successful in wound healing.
生物活性玻璃长期以来一直用于矿化组织再生的研究，但最近它们在软组织修复，特别是伤口愈合方面的潜在应用显示出了巨大的前景。常用的玻璃，如基于硅酸盐的生物活性玻璃45S5 [（46.1）SiO-（26.9）CaO-（24.4）NaO-（2.6）PO（摩尔%）] 和基于硼酸盐的13-93B3 [（54）BO-（22）CaO-（6）NaO-（8）KO-（8）MgO-（2）PO（摩尔%）] 已被证实参与伤口愈合的各个阶段，因为它们能够释放离子，刺激诸如止血、抗菌效果、上皮细胞迁移、血管生成和成纤维细胞增殖等过程。最近，一种由硼酸盐基玻璃制成的伤口敷料已获得监管批准，可用于治疗急性和慢性伤口。然而，迄今为止，关于它们在加速伤口愈合过程中的具体作用机制尚无全面报道。在本综述中，我们将简要概述伤口愈合阶段，回顾已研究的在伤口愈合中具有潜在应用的生物活性玻璃配方，并试图总结关于这些玻璃为何可能成功促进伤口愈合的共识。
