Zheng Yadan, Lu Hongguang, Jiang Zhu, Guan Yue, Zou Jialing, Wang Xian, Cheng Ruoyu, Gao Hui
Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, P. R. China.
J Mater Chem B. 2017 Aug 21;5(31):6277-6281. doi: 10.1039/c7tb01443k. Epub 2017 Jul 24.
Photodynamic therapy (PDT) has received enormous attention due to its high specificity in eliminating the malignant tumor cells without interposing normal cells, as compared with chemotherapy. In this work, we fabricated mitochondria-targeted NPs using a new AIE cross-linked copolymer (PAIE-TPP) with far red/near-infrared (FR/NIR) subcellular bioimaging ability and a high reactive oxygen species (ROS) quantum yield of 77.9%. Such high efficiency ROS generation is desirable to increase the efficiency of PDT. The PAIE-TPP NPs possess great cytocompatibility but exert severe cytotoxicity to cancer cells with only 4% of cell viability under ultralow-power-intensity (10 mW cm) light irradiation. The AIE cross-linked copolymer NPs not only emit bright FR/NIR fluorescence for efficient in vitro subcellular-mitochondrial bioimaging but also generate high ROS for PDT.
与化疗相比，光动力疗法（PDT）因其在消除恶性肿瘤细胞时具有高度特异性且不干扰正常细胞而受到广泛关注。在这项工作中，我们使用一种新型的具有远红/近红外（FR/NIR）亚细胞生物成像能力且活性氧（ROS）量子产率高达77.9%的聚集诱导发光交联共聚物（PAIE-TPP）制备了线粒体靶向纳米粒子。如此高效地产生ROS对于提高光动力疗法的效率是非常有必要的。PAIE-TPP纳米粒子具有良好的细胞相容性，但在超低功率强度（10 mW/cm²）光照下，对癌细胞具有严重的细胞毒性，细胞活力仅为4%。这种聚集诱导发光交联共聚物纳米粒子不仅能发出明亮的FR/NIR荧光以实现高效的体外亚细胞线粒体生物成像，还能产生高浓度的ROS用于光动力疗法。
