McEwen Holly, Du Eric Y, Mata Jitendra P, Thordarson Pall, Martin Adam D
School of Chemistry, the Australian Centre for Nanomedicine and the ARC Centre for Convergent Bio-Nano Science and Technology, University of New South Wales, Sydney, NSW 2052, Australia.
J Mater Chem B. 2017 Dec 21;5(47):9412-9417. doi: 10.1039/c7tb02140b. Epub 2017 Nov 27.
Two N-terminal capped tripeptides have been synthesised and display remarkable versatility in their gelation behaviour. Here, gelation can be triggered through the addition of an acid, biologically relevant metal salts or cell culture media. The structural and mechanical properties of the resultant hydrogels are tuneable, with gelation triggered through sodium cations amplifying secondary structure organisation yet decreasing gel stiffness. The effect of gelation trigger on cell viability is evaluated, with substantial improvement in cell survival observed when gelation is triggered using metal salts or cell culture media.
已经合成了两种N端封端的三肽，它们在凝胶化行为方面表现出显著的多功能性。在这里，通过添加酸、具有生物学相关性的金属盐或细胞培养基可以触发凝胶化。所得水凝胶的结构和力学性能是可调的，通过钠离子触发凝胶化可增强二级结构组织，但会降低凝胶硬度。评估了凝胶化触发因素对细胞活力的影响，当使用金属盐或细胞培养基触发凝胶化时，观察到细胞存活率有显著提高。
