Jia Xinghang, Ahmad Israr, Yang Rong, Wang Chen
CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Nanotechnology, Beijing, 100190, P. R. China.
J Mater Chem B. 2017 Apr 7;5(13):2459-2467. doi: 10.1039/c6tb03084j. Epub 2017 Mar 15.
Bacterial infection is a worldwide health problem. Finding new potential antibacterial materials and developing advanced treatment strategies are becoming increasingly important and urgent. Herein, a versatile graphene-based photothermal nanocomposite was prepared for rapidly capturing and effectively eliminating both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli), and for destroying bacterial biofilms with near-infrared (NIR) irradiation. In this work, chitosan-functionalized magnetic graphene oxide (GO-IO-CS) was synthesized as a multifunctional therapy agent through a hydrothermal method. Chitosan could efficiently contact and capture bacteria by its positively charged surface functional groups, and graphene oxide could act as an effective photothermal killer to convert NIR light into local heat to enhance antibacterial activity. The super-paramagnetic properties of GO-IO-CS made it easy to separate and aggregate the bacteria, so improving the photothermal sterilization efficiency. GO-IO-CS was demonstrated to eliminate bacteria effectively after 10 min of NIR irradiation and to destroy bacterial biofilms. Furthermore, this antibiotic agent could be regenerated with an external magnet and reused in a subsequent antibacterial application.
细菌感染是一个全球性的健康问题。寻找新的潜在抗菌材料并开发先进的治疗策略变得越来越重要和紧迫。在此，制备了一种多功能的基于石墨烯的光热纳米复合材料，用于快速捕获并有效消除革兰氏阳性金黄色葡萄球菌（S. aureus）和革兰氏阴性大肠杆菌（E. coli），以及利用近红外（NIR）照射破坏细菌生物膜。在这项工作中，通过水热法合成了壳聚糖功能化的磁性氧化石墨烯（GO-IO-CS）作为多功能治疗剂。壳聚糖可以通过其带正电荷的表面官能团有效地接触和捕获细菌，氧化石墨烯可以作为有效的光热杀伤剂，将近红外光转化为局部热量以增强抗菌活性。GO-IO-CS的超顺磁性使其易于分离和聚集细菌，从而提高光热杀菌效率。结果表明，GO-IO-CS在近红外照射10分钟后能有效消除细菌并破坏细菌生物膜。此外，这种抗菌剂可以用外部磁铁再生，并在后续的抗菌应用中重复使用。
