Wu Jiali, Lin Su, Liu Shiying, Wan Bo, Lin Yehong, Wang Mingfang, Zhu Yueyong
Liver Research Center of the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Faculty of Life Science and Medicine, King's College, London, UK.
J Int Med Res. 2020 Apr;48(4):300060520910906. doi: 10.1177/0300060520910906.
To investigate the relationship between vitamin D-related gene single nucleotide polymorphisms (SNPs) and hepatitis B-related liver cirrhosis.
This study included patients with chronic hepatitis B who were admitted to the Liver Research Center of the First Affiliated Hospital of Fujian Medical University from July 2012 to August 2016. SNPs rs1544410 and rs2228570 in the vitamin D receptor gene and rs2282679 in the vitamin D-binding protein gene were detected using the imLDR™ multiple SNP typing kit. Genotype and allele frequencies were compared between groups using the chi-square test or Fisher’s exact test.
A total of 226 patients with hepatitis B virus (HBV) infection were enrolled, including 116 with HBV-related cirrhosis and 110 patients without. The distributions of vitamin D-related gene SNPs in both groups were in accordance with the Hardy–Weinberg equilibrium. There was no significant difference in the frequency or allelic distributions of rs1544410, rs2228570, and rs2282679 between the two groups. Additionally, the SNPs were not associated with the severity of cirrhosis.
No significant connection was identified between vitamin D-related SNPs and HBV-related liver cirrhosis.
探讨维生素D相关基因单核苷酸多态性（SNP）与乙型肝炎相关性肝硬化之间的关系。
本研究纳入了2012年7月至2016年8月在福建医科大学附属第一医院肝脏研究中心住院的慢性乙型肝炎患者。使用imLDR™多重SNP分型试剂盒检测维生素D受体基因中的SNP rs1544410和rs2228570以及维生素D结合蛋白基因中的rs2282679。使用卡方检验或Fisher精确检验比较组间的基因型和等位基因频率。
共纳入226例乙型肝炎病毒（HBV）感染患者，其中116例为HBV相关性肝硬化患者，110例为非肝硬化患者。两组中维生素D相关基因SNP的分布均符合Hardy-Weinberg平衡。两组之间rs1544410、rs2228570和rs2282679的频率或等位基因分布无显著差异。此外，这些SNP与肝硬化的严重程度无关。
未发现维生素D相关SNP与HBV相关性肝硬化之间存在显著关联。
