接种疫苗后移植物功能障碍/再生障碍性贫血复发伴自体CD8 +淋巴细胞大量克隆性扩增。
Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes.
作者信息
Ritz Caitlin, Meng Wenzhao, Stanley Natasha L, Baroja Miren L, Xu Chong, Yan Patrick, Huang Alexander C, Hausler Ryan, Nicholas Peter, Fan Jian-Meng, Lieberman David, Carreno Beatriz M, Luning Prak Eline T, Olson Timothy S, Babushok Daria V
机构信息
Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.
Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA.
出版信息
Blood Adv. 2020 Apr 14;4(7):1378-1382. doi: 10.1182/bloodadvances.2019000853.
Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger. Clonal expansion of CD8 effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse.
获得性再生障碍性贫血是一种由T细胞介导的自身免疫性骨髓再生障碍，病因不明。接种疫苗后可发生CD8效应性T淋巴细胞的克隆性扩增，并伴有移植物功能障碍或再生障碍性贫血复发。
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