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接种疫苗后移植物功能障碍/再生障碍性贫血复发伴自体CD8 +淋巴细胞大量克隆性扩增。

Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes.

作者信息

Ritz Caitlin, Meng Wenzhao, Stanley Natasha L, Baroja Miren L, Xu Chong, Yan Patrick, Huang Alexander C, Hausler Ryan, Nicholas Peter, Fan Jian-Meng, Lieberman David, Carreno Beatriz M, Luning Prak Eline T, Olson Timothy S, Babushok Daria V

机构信息

Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA.

出版信息

Blood Adv. 2020 Apr 14;4(7):1378-1382. doi: 10.1182/bloodadvances.2019000853.

DOI:10.1182/bloodadvances.2019000853
PMID:32267929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7160279/
Abstract

Acquired aplastic anemia is a T-cell–mediated autoimmune bone marrow aplasia, without a known etiologic trigger. Clonal expansion of CD8 effector T lymphocytes can occur following vaccination and accompany graft dysfunction or aplastic anemia relapse.

摘要

获得性再生障碍性贫血是一种由T细胞介导的自身免疫性骨髓再生障碍，病因不明。接种疫苗后可发生CD8效应性T淋巴细胞的克隆性扩增，并伴有移植物功能障碍或再生障碍性贫血复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51f/7160279/ca56441b888e/advancesADV2019000853absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51f/7160279/ca56441b888e/advancesADV2019000853absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b51f/7160279/ca56441b888e/advancesADV2019000853absf1.jpg

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