NADH 将一碳代谢与细胞呼吸联系起来。
NADH Ties One-Carbon Metabolism to Cellular Respiration.
机构信息
Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA.
出版信息
Cell Metab. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012.
In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.
在本期《细胞代谢》中，Yang 等人 2020 年报道称丝氨酸是来源于一碳代谢的线粒体 NADH 的来源。当细胞呼吸受到抑制时，丝氨酸成为 NADH 的主要来源，而未被利用的积累 NADH 会抑制 TCA 循环并减缓增殖。
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