Schuhladen Katharina, Mukoo Pratishtha, Liverani Liliana, Neščáková Zuzana, Boccaccini Aldo R
Department of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.
Department of Biomaterials, FunGlass, Alexander Dubček University of Trenčín, Študentská 2, 91150 Trenčín, Slovakia.
Biomed Mater. 2020 Sep 19;15(6):065002. doi: 10.1088/1748-605X/ab87e5.
Wound dressings able to deliver topically bioactive molecules represent a new generation of wound-regeneration therapies. In this article, foams based on methylcellulose cross-linked with Manuka honey were used as a platform to deliver borate bioactive glass particles doped additionally with copper. Borate bioactive glasses are of great interest in wound-healing applications due to a combination of favorable features, such as angiogenic and antibacterial properties. The multifunctional composite providing the dual effect of the bioactive glass and Manuka honey was produced by freeze-drying, and the resulting foams exhibit suitable morphology characterized by high porosity. Moreover, the performed tests showed improved wettability and mechanical performance with the addition of bioactive glass particles. Dissolution studies using simulated body fluid and cell biology tests using relevant skin cells further proved the excellent bioactivity and positive effects of the foams on cell proliferation and migration. Most interestingly, by the dual release of Manuka honey and ions from the copper-doped bioactive glass, an antibacterial effect against E. coli and S. aureus was achieved. Therefore, the multifunctional foams showed promising outcomes as potential wound dressings for the treatment of infected wounds.
能够局部递送生物活性分子的伤口敷料代表了新一代伤口再生疗法。在本文中，基于与麦卢卡蜂蜜交联的甲基纤维素的泡沫被用作一个平台，以递送额外掺杂铜的硼酸盐生物活性玻璃颗粒。硼酸盐生物活性玻璃由于具有诸如促血管生成和抗菌特性等有利特征的组合，在伤口愈合应用中备受关注。通过冷冻干燥制备了具有生物活性玻璃和麦卢卡蜂蜜双重作用的多功能复合材料，所得泡沫呈现出以高孔隙率为特征的合适形态。此外，进行的测试表明，添加生物活性玻璃颗粒后，润湿性和机械性能得到改善。使用模拟体液的溶解研究和使用相关皮肤细胞的细胞生物学测试进一步证明了泡沫具有优异的生物活性以及对细胞增殖和迁移的积极作用。最有趣的是，通过麦卢卡蜂蜜和来自掺杂铜的生物活性玻璃的离子的双重释放，实现了对大肠杆菌和金黄色葡萄球菌的抗菌作用。因此，多功能泡沫作为治疗感染伤口的潜在伤口敷料显示出有前景的结果。
