Department of biomedical Science, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan.
Future Med Chem. 2020 May;12(10):939-947. doi: 10.4155/fmc-2019-0307. Epub 2020 Apr 9.
A new medicine will take an average of 10-15 years and more than US$2 billion before it can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the main source of new drug entities, but was later shifted toward high-throughput synthesis and combinatorial chemistry-based development. New technologies such as ultra-high-throughput drug screening and artificial intelligence are being heavily employed to reduce the cost and the time of early drug discovery, but they remain relatively unchanged. However, are there other potentially faster and cheaper means of drug discovery? Is drug repurposing a viable alternative? In this review, we discuss the different means of drug discovery including their advantages and disadvantages.
一种新药的研发平均需要 10-15 年，并且需要超过 20 亿美元才能上市。传统上，药物发现依赖于天然产物作为新药实体的主要来源，但后来转向基于高通量合成和组合化学的开发。超高效药物筛选和人工智能等新技术正被大量用于降低早期药物发现的成本和时间，但它们相对不变。然而，是否有其他潜在的更快、更便宜的药物发现方法？药物再利用是一种可行的替代方案吗？在这篇综述中，我们讨论了不同的药物发现方法，包括它们的优缺点。
