EA7516 « CHIMERE », Université de Picardie Jules Verne, Amiens, France; Department of Biochemistry, Centre de Biologie Humaine, CHU, Amiens, France.
EA7516 « CHIMERE », Université de Picardie Jules Verne, Amiens, France; Department of Molecular Oncobiology, Centre de Biologie Humaine, CHU, Amiens, France.
Cancer Lett. 2020 Jul 1;481:45-54. doi: 10.1016/j.canlet.2020.04.004. Epub 2020 Apr 6.
The identification of the biological determinants that shape the response of tumors to medical therapies offers perspectives for better patient stratification and therapeutic targeting. Here, we discuss how genomics could help to improve the surgical treatment of head and neck squamous cell carcinoma (HNSCC). We examine the potential use of genomic analyses for: i) refining and standardizing the indications for surgery, ii) the choice of surgical procedure, and iii) the follow-up of patients with resected tumors. We highlight the studies that used genomics to explore the contribution of tumor biology to the outcome of surgery. We discuss the important developments that are challenging current surgical practice in HNSCC, such as neoadjuvant immunotherapy and the analysis of circulating DNA. Genomic analyses provide practical tools that could help improve the pathological diagnosis and staging of HNSCC, and increase the appreciation of the importance of tumor biology in the outcome of surgery. Identification of biomarkers will likely contribute to a move toward precision surgery of HNSCC, i.e. the personalization of surgical practice based on tumor biology.
确定影响肿瘤对医学治疗反应的生物学决定因素，为更好地进行患者分层和治疗靶向提供了思路。在这里，我们讨论了基因组学如何有助于改善头颈部鳞状细胞癌 (HNSCC) 的手术治疗。我们研究了基因组分析在以下方面的潜在用途：i）细化和标准化手术适应证，ii）选择手术程序，以及 iii）对接受肿瘤切除术的患者进行随访。我们强调了使用基因组学探索肿瘤生物学对手术结果的贡献的研究。我们讨论了正在挑战当前 HNSCC 手术实践的重要发展，例如新辅助免疫治疗和循环 DNA 分析。基因组分析提供了实用的工具，可以帮助改善 HNSCC 的病理诊断和分期，并提高对肿瘤生物学在手术结果中的重要性的认识。生物标志物的鉴定可能有助于实现 HNSCC 的精准手术，即根据肿瘤生物学对手术实践进行个体化。
