Rapson E B, Lee D L, Watts S D
Mol Biochem Parasitol. 1981 Nov;4(1-2):9-15. doi: 10.1016/0166-6851(81)90024-4.
Acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) activities of Nippostrongylus brasiliensis were measured following treatment of the hosts with oxfendazole and mebendazole. Drug treatment of N. Brasiliensis caused large, sustained increases in enzyme activity in male and female worms which coincided with the expulsion of the nematodes from the small intestine of the host. It is suggested that the increases in acetylcholinesterase activity may be due to an inhibition by the benzimidazole carbamates of the secretion of enzyme to the exterior of the worms which, in turn, leads to expulsion through failure of the so-called "chemical holdfast".
在用奥芬达唑和甲苯达唑处理宿主后，测定了巴西日圆线虫的乙酰胆碱酯酶（乙酰胆碱水解酶，EC 3.1.1.7）活性。对巴西日圆线虫进行药物处理后，雌雄虫体内的酶活性大幅持续增加，这与线虫从宿主小肠排出的情况相符。有人认为，乙酰胆碱酯酶活性的增加可能是由于苯并咪唑氨基甲酸盐抑制了酶向虫体外分泌，进而导致所谓的“化学固着”失效而引起排出。
