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无尿血液透析患者复发性尿路感染的治疗,我们真的需要抗菌药物在尿液中达到有效浓度吗?

Treatment of recurrent urinary tract infections in anuric hemodialysis patient, do we really need antimicrobial urinary concentration?

作者信息

El Nekidy Wasim S, Soong Derrick, Mooty Mohamad, Ghazi Islam M

机构信息

Cleveland Clinic, Abu Dhabi, United Arab Emirates and Cleveland Clinic Lerner College of Medicine, Case Western University, Cleveland, OH, USA.

Windsor Regional Hospital, Windsor, ON, Canada.

出版信息

IDCases. 2020 Mar 21;20:e00748. doi: 10.1016/j.idcr.2020.e00748. eCollection 2020.

DOI:10.1016/j.idcr.2020.e00748
PMID:32274331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7132144/
Abstract

Providing care for patients with chronic kidney disease requires considerations that are unique to this population. Several references recommend the treating urinary tract infections with antibiotics that achieve considerable concentrations in urine however this is not applicable in anuric patients undergoing hemodialysis who are unable to excrete antibiotics significantly in urine. We report successful treatment of several episodes of urinary tract infections in hemodialysis patient highlighting the questionable need for antimicrobial urine concentration.

摘要

为慢性肾病患者提供护理需要考虑该人群特有的因素。一些参考文献建议使用在尿液中能达到较高浓度的抗生素来治疗尿路感染,然而这并不适用于正在接受血液透析且无尿的患者,因为他们无法在尿液中大量排泄抗生素。我们报告了对一名血液透析患者多次尿路感染的成功治疗,突出了对抗菌药物尿液浓度需求的存疑之处。

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本文引用的文献

1
A practical thrice weekly ertapenem in hemodialysis patients.血液透析患者每三周一次使用厄他培南的实用方案。
Antimicrob Agents Chemother. 2019 Sep 9;63(12). doi: 10.1128/AAC.01427-19. Epub 2019 Sep 16.
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Salvage of Hemodialysis Catheter in Staphylococcal Bacteremia: Case Series, Revisiting the Literature, and the Role of the Pharmacist.金黄色葡萄球菌菌血症中血液透析导管的挽救:病例系列、文献回顾及药师的作用
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A practical thrice weekly Ertapenem dosage regime for chronic hemodialysis patients?一种适用于慢性血液透析患者的每周三次厄他培南实用给药方案?
Clin Nephrol. 2013 Oct;80(4):312. doi: 10.5414/cn108071.
7
Factors influencing vancomycin loading dose for hospitalized hemodialysis patients: prospective observational cohort study.影响住院血液透析患者万古霉素负荷剂量的因素:前瞻性观察队列研究
Can J Hosp Pharm. 2012 Nov;65(6):436-42. doi: 10.4212/cjhp.v65i6.1191.
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Comparison of alteplase (tissue plasminogen activator) high-dose vs. low-dose protocol in restoring hemodialysis catheter function: the ALTE-DOSE study.阿替普酶(组织型纤溶酶原激活剂)高剂量与低剂量方案恢复血液透析导管功能的比较:ALTE-DOSE研究
Hemodial Int. 2013 Jul;17(3):434-40. doi: 10.1111/hdi.12004. Epub 2012 Nov 26.
9
International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: A 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases.国际临床实践指南:女性急性单纯性膀胱炎和肾盂肾炎的治疗(2010 年更新):美国传染病学会和欧洲临床微生物学和传染病学会。
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Use of antibacterial agents in renal failure.肾衰竭患者中的抗菌药物应用。
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