[穴位隔药饼灸对糖尿病胃轻瘫患者血浆胃动素及血清胃泌素的影响]

[Effect of herb-partitioned moxibustion at point on plasma motilin and serum gastrin in patients of diabetic gastroparesis].

作者信息

Meng Na, Shi Zhi-Min

机构信息

Second Department of Endocrinology, Tangshan Gongren Hospital, Tangshan 063000, Hebei Province, China.

Department of Spleen and Stomach Disorders, Tangshan TCM Hospital, Tangshan 063000, Hebei Province.

出版信息

Zhongguo Zhen Jiu. 2020 Apr 12;40(4):361-4. doi: 10.13703/j.0255-2930.20190415-0001.

DOI:10.13703/j.0255-2930.20190415-0001

PMID:32275362

Abstract

OBJECTIVE

To explore the clinical therapeutic effect of herb-partitioned moxibustion at point in patients of diabetic gastroparesis differentiated as spleen and stomach deficiency and retention of turbid dampness as well as its effect mechanism.

METHODS

A total of 134 patients with diabetic gastroparesis were randomized into an observation group and a control group, 67 cases in each one. In the observation group, herb-partitioned moxibustion at point was adopted, 40 min each time, once a day for 5 times a week. In the control group, itopride hydrochloride tablets were prescribed for oral administration, 50 mg each time, three times a day. A total of 6 weeks of treatment was required in the two groups. Before and after treatment, the gastroparesis cardinal symptom index (GCSI) scores, 4-hour gastric emptying rate, TCM symptom score, as well as the levels of plasma motilin and serum gastrin were observed in the patients of the two groups. Additionally, the clinical therapeutic effect was evaluated in the two groups.

RESULTS

After treatment, the score of every item of GCSI, TCM symptom scores and the levels of plasma motilin and serum gastrin were all reduced as compared with those before treatment in the patients of the two groups (<0.05), and those in the observation group were lower than the control group (<0.05). Regarding 4-hour gastric emptying rates, which were increased as compared with those before treatment in the two group (<0.05), and the rate in the observation group was higher remarkably than that in the control group (<0.05). The total effective rate was 92.5% (62/67) in the observation group, higher than 74.6% (50/67) in the control group (<0.05).

CONCLUSION

Herb-partitioned moxibustion at point relieves the clinical symptoms in the patients with diabetic gastroparesis and increases the gastric emptying rate, which is probably related to the regulation of the levels of plasma motilin and serum gastrin.

摘要

目的

探讨隔药饼灸中脘穴对辨证为脾胃虚弱兼湿浊内蕴型糖尿病胃轻瘫患者的临床治疗效果及其作用机制。

方法

将134例糖尿病胃轻瘫患者随机分为观察组和对照组，每组67例。观察组采用隔药饼灸中脘穴，每次40分钟，每天1次，每周5次。对照组口服盐酸伊托必利片，每次50毫克，每天3次。两组均需治疗6周。治疗前后，观察两组患者的胃轻瘫主要症状指数（GCSI）评分、4小时胃排空率、中医症状评分以及血浆胃动素和血清胃泌素水平。此外，对两组的临床治疗效果进行评估。

结果

治疗后，两组患者的GCSI各项评分、中医症状评分以及血浆胃动素和血清胃泌素水平均较治疗前降低（<0.05），且观察组低于对照组（<0.05）。关于4小时胃排空率，两组均较治疗前升高（<0.05），且观察组显著高于对照组（<0.05）。观察组总有效率为92.5%（62/67），高于对照组的74.6%（50/67）（<0.05）。