Vector Biology and Control, Indian Council of Medical Research-Vector Control Research Centre , Puducherry, India.
Pathog Glob Health. 2020 May 18;114(4):205-211. doi: 10.1080/20477724.2020.1751999. Epub 2020 Apr 10.
. is the principal malaria vector in India and has recently developed resistance to synthetic pyrethroids. For identifying the possible operational impact, quantitative measure of the intensity of this resistance is required. The purpose of this study was to measure the intensity of pyrethroid resistance in . The intensity bioassays with wild caught were carried out in 10 districts of east central India using 5x and 10x diagnostic concentrations of deltamethrin following WHO insecticides susceptibility guidelines. The results showed that the mortality of . ranged from 70% to 80% while exposed to 1x DC of deltamethrin (0.05%). Further bioassays conducted with 5x concentration of deltamethrin (0.25%) showed that the mortality of . in all the 10 districts varied from 92% to 97% indicating moderate resistance. While exposing to 10x concentration (0.5%) of this insecticide, 100% mortality was observed in all the districts; thereby confirmed moderate resistance intensity of this species. Since resistance was not confirmed at the 10x concentration, operational failure of this insecticide was unlikely. Hence, it is recommended to continue the use of LLINs for malaria vector control in these areas.
是印度的主要疟疾传播媒介，最近已对合成拟除虫菊酯产生抗药性。为了确定可能的实际影响，需要对这种抗药性的强度进行定量测量。本研究的目的是测量 在印度东部 10 个地区进行的野外捕获 的强度生物测定，使用 5x 和 10x 的氯菊酯诊断浓度，遵循世界卫生组织杀虫剂敏感性指南。结果表明， 在接触 1x 的氯菊酯（0.05%）时， 的死亡率在 70%到 80%之间。进一步用 5x 浓度的氯菊酯（0.25%）进行的生物测定表明， 在所有 10 个地区的死亡率在 92%到 97%之间，表明存在中度抗性。当暴露于该杀虫剂的 10x 浓度（0.5%）时，所有地区的死亡率均为 100%；从而证实了该物种的中度抗性强度。由于在 10x 浓度下未确认抗性，因此该杀虫剂不太可能出现实际效果失败。因此，建议在这些地区继续使用长效驱虫蚊帐来控制疟疾媒介。
