Brasseur R, Lorge P, Goormaghtigh E, Ruysschaert J M, Espion D, Burny A
Laboratory of Macromolecules at Interfaces, Brussels, Belgium.
Virus Genes. 1988 Jul;1(4):325-32. doi: 10.1007/BF00257096.
A protein sequence of the viral envelope is responsible for the fusion of the viral membrane with the cell membrane. It has been hypothesized that this fusion protein acts by inserting its hydrophobic moiety into the target membrane. The paper reports on the mode of insertion of the Newcastle disease virus (NDV) fusion protein N-terminus peptide into a lipid membrane using infrared spectroscopy and conformational analysis. The peptide was shown to adopt an oblique orientation with respect to the lipid acyl chains. This unusual orientation is expected to induce the disorganization of the surrounding lipids, which had been suggested as one of the initial events in the virus/cell fusion.
病毒包膜的一种蛋白质序列负责病毒膜与细胞膜的融合。据推测，这种融合蛋白通过将其疏水部分插入靶膜来发挥作用。该论文报道了利用红外光谱和构象分析研究新城疫病毒（NDV）融合蛋白N端肽插入脂质膜的方式。结果表明，该肽相对于脂质酰基链呈倾斜取向。这种不寻常的取向预计会导致周围脂质的无序化，这被认为是病毒/细胞融合的初始事件之一。
