Murphy S B, Aur R J, Simone J V, George S, Mauer A M
Blood. 1977 May;49(5):683-91.
The relationship of the pretreatment bone marrow mitotic index (MI) and in vitro 3H-thymidine labeling index (LI) to other variables present at diagnosis and to the outcome of standard therapy was examined in a series of 94 children with acute leukemia (71 ALL, 23 AML). The range of observed values at diagnosis was extremely broad, from less than 1% labeled cells to more than 25%. The median LI% for all patients studied was 5.2%; the median MI% was 0.3%. The values for AML and ALL did not differ significantly despite older age, higher initial white blood cell (WBC) counts, and poorer response to therapy of AML patients. The initial MI and LI were positively correlated with each other, but unrelated to age or initial WBC count in either ALL or AML. However, the LI and MI were significantly higher (p less than 0.01) in the group of 10 children of 54 studied with ALL whose blasts formed spontaneous rosettes with sheep red blood cells at 37 degrees C. The initial LI and MI were not shown to be related to the likelihood of attaining a complete response or to the length of remission in either ALL or AML. There was thus no evidence that either the initial MI or LI% of marrow blasts was of any prognostic significance in children with acute leukemia.
在94例急性白血病患儿（71例急性淋巴细胞白血病、23例急性髓细胞白血病）中，研究了预处理骨髓有丝分裂指数（MI）和体外3H-胸腺嘧啶核苷标记指数（LI）与诊断时存在的其他变量以及标准治疗结果之间的关系。诊断时观察值的范围非常广泛，从标记细胞少于1%到超过25%。所有研究患者的LI%中位数为5.2%；MI%中位数为0.3%。尽管急性髓细胞白血病患者年龄较大、初始白细胞（WBC）计数较高且对治疗反应较差，但急性髓细胞白血病和急性淋巴细胞白血病的值并无显著差异。初始MI和LI彼此呈正相关，但与急性淋巴细胞白血病或急性髓细胞白血病中的年龄或初始WBC计数均无关。然而，在54例研究的急性淋巴细胞白血病患儿中，有10例其原始细胞在37℃下与绵羊红细胞形成自发玫瑰花结，该组患儿的LI和MI显著更高（p< 0.01）。在急性淋巴细胞白血病或急性髓细胞白血病中，初始LI和MI均未显示与获得完全缓解的可能性或缓解期长度相关。因此，没有证据表明骨髓原始细胞的初始MI或LI%对急性白血病患儿具有任何预后意义。
