Ffrench M, Magaud J P, Manel A M, Adeleine P, Devaux Y, Fiere D, Philippe N, Souillet G, Bryon P A
Service et Laboratoire d'Hématologie, Hôpital E. Herriot, Faculté Lyon Nord, France.
Br J Cancer. 1989 Mar;59(3):401-6. doi: 10.1038/bjc.1989.80.
Cell kinetics were studied in 124 patients with acute lymphoblastic leukaemia (ALL) by flow cytometry, comparing cell cycle characteristics between adults (57 cases) and children (67 cases). S, G2 + M and the low protein content fraction of G1 (LPC fraction) were determined and studied in relation to other clinical and biological features. No difference was found between adults and children in the distribution of these variables. The proliferative rates according to organomegaly, leukocytosis, the FAB cytological groups and the immunological groups did not present any significant differences between the two groups of patients. However, cell cycle did seem to have a very different prognostic value for adults and for children. G2 + M was a strong prognostic indicator for childhood ALL: duration of CR and survival were significantly longer when G2 + M was higher (P less than 0.01). In adults, survival was longer for intermediary (between 3.8 and 5.8%) and high (over 7.2%) G2 + M values (P less than 0.01). The negative correlation between S and G2 + M observed in adults and the absence of correlation in children raise the possibility of differences in duration of the different phases for the two groups and perhaps an accumulation of cells in G2 or tetraploidy in some cases.
通过流式细胞术对124例急性淋巴细胞白血病（ALL）患者的细胞动力学进行了研究，比较了成人（57例）和儿童（67例）之间的细胞周期特征。测定并研究了S期、G2 + M期以及G1期低蛋白含量部分（LPC部分），并将其与其他临床和生物学特征相关联。在这些变量的分布上，成人和儿童之间未发现差异。根据器官肿大、白细胞增多、FAB细胞学分组和免疫分组得出的增殖率，两组患者之间未呈现任何显著差异。然而，细胞周期对成人和儿童似乎具有非常不同的预后价值。G2 + M是儿童ALL的一个强有力的预后指标：当G2 + M较高时，CR持续时间和生存期显著更长（P小于0.01）。在成人中，G2 + M值处于中等水平（3.8%至5.8%之间）和高水平（超过7.2%）时生存期更长（P小于0.01）。在成人中观察到的S期与G2 + M期之间的负相关以及儿童中不存在相关性，增加了两组不同阶段持续时间存在差异的可能性，并且在某些情况下可能存在G2期细胞积累或四倍体现象。
