Ekert H, Dobrostanski B, Jose D G, Waters K D, Ellis W M
Med Pediatr Oncol. 1978;5(1):177-82. doi: 10.1002/mpo.2950050124.
"The labelling index (LI), mitotic index (MI) of marrow lymphoblasts and the percent of peripheral blood lymphocytes and lymphoblasts that form rosettes with sheep red cells at 4 degrees C ("T4"), were measured at presentation in 33 children with ALL. There was a significant correlation between LI and MI, but no significant correlations between them and the total white cell count at diagnosis or the "T4" percent. Three patients had greater than 55% "T4" rosettes and showed increased LI and MI, and 2 have relapsed; 12 had less than 20% "T4" rosettes, showed an increased LI (LI greater than 8% in 8 of 12) but not MI, and 5 have relapsed; 18 had 20--55% "T4" rosettes and generally had the lowest LI (LI less than 8% in 11 of 18), and only 3 have relapsed. Our findings suggest that patients with high and low percentage of "T4" rosettes in the peripheral blood have an increased fraction of leukaemic cells in DNA synthesis and have a diminished chance of prolonged remission.
对33例急性淋巴细胞白血病患儿初诊时测定其骨髓淋巴母细胞的标记指数（LI）、有丝分裂指数（MI）以及4℃下与绵羊红细胞形成玫瑰花结的外周血淋巴细胞和淋巴母细胞的百分比（“T4”）。LI与MI之间存在显著相关性，但它们与诊断时的白细胞总数或“T4”百分比之间无显著相关性。3例患儿“T4”玫瑰花结大于55%，LI和MI升高，其中2例复发；12例患儿“T4”玫瑰花结小于20%，LI升高（12例中有8例LI大于8%）但MI未升高，其中5例复发；18例患儿“T4”玫瑰花结为20% - 55%，通常LI最低（18例中有11例LI小于8%），仅3例复发。我们的研究结果表明，外周血中“T4”玫瑰花结百分比高和低的患者，其白血病细胞进行DNA合成的比例增加，长期缓解的机会减少。
