Poznan University of Physical Education, Department of Physiology and Biochemistry, Poznań, Poland.
State University of Applied Science in Nowy Sącz, Department of Physiotherapy, Nowy Sącz, Poland.
Sci Rep. 2020 Apr 10;10(1):6175. doi: 10.1038/s41598-020-63002-x.
Skeletal muscle and adipose tissue play an important role in maintaining metabolic homeostasis and thermogenesis. We aimed to investigate the effects of single and repeated exposure to whole-body cryotherapy in volunteers with different physical fitness levels on 25-hydroxyvitamin D (25(OH)D) and myokines. The study included 22 healthy male volunteers (mean age: 21 ± 1.17 years), who underwent 10 consecutive sessions in a cryogenic chamber once daily (3 minutes, -110 °C). Blood samples were collected before and 30 minutes and 24 hours after the first and last cryotherapy sessions. Prior to treatment, body composition and physical fitness levels were measured. After 10 cryotherapy treatments, significant changes were found in myostatin concentrations in the low physical fitness level (LPhL) group. The 25(OH)D levels were increased in the high physical fitness level (HPhL) group and decreased in the LPhL group. The HPhL group had significant changes in the level of high-sensitivity interleukin-6 after the first treatment. The LPhL group had significant changes in 25(OH)D, irisin, and myostatin levels after the tenth treatment. Our data demonstrated that in healthy young men, cryotherapy affects 25(OH)D levels, but they were small and transient. The body's response to a series of 10 cryotherapy treatments is modified by physical fitness level.
骨骼肌和脂肪组织在维持代谢稳态和产热方面起着重要作用。我们旨在研究单次和重复暴露于全身冷冻疗法对不同身体适应水平的志愿者 25-羟维生素 D（25（OH）D）和肌因子的影响。该研究包括 22 名健康男性志愿者（平均年龄：21 ± 1.17 岁），他们每天在冷冻室中连续进行 10 次治疗（3 分钟，-110°C）。在第一次和最后一次冷冻治疗前后 30 分钟和 24 小时采集血液样本。在治疗前，测量身体成分和身体适应水平。经过 10 次冷冻治疗后，低身体适应水平（LPhL）组的肌肉生长抑制素浓度发生显著变化。高身体适应水平（HPhL）组的 25（OH）D 水平升高，LPhL 组的水平降低。第一次治疗后，HPhL 组的高敏白细胞介素-6 水平发生显著变化。第十次治疗后，LPhL 组的 25（OH）D、鸢尾素和肌肉生长抑制素水平发生显著变化。我们的数据表明，在健康的年轻男性中，冷冻疗法会影响 25（OH）D 水平，但影响较小且短暂。身体对一系列 10 次冷冻治疗的反应受到身体适应水平的影响。
