Mu Shuai, Huang Chongjun, Chen Bobo, Zhao Pengyu, Xu Haoran, Zhang Weihao, Dai Huixu
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Physiol. 2023 Jun 26;14:1210457. doi: 10.3389/fphys.2023.1210457. eCollection 2023.
Cold and exercise are two important stimuli affecting the secretion of osteokines and adipomyokines, which often occur simultaneously. However, few studies have investigated the changes in osteokines and adipomyokines induced by exercise during severe cold and their corresponding associations. Therefore, this study aimed to investigate the changes in sclerostin and meteorin-like (metrnl) protein before and after cold exercise (ice swimming [IS]) and observe their correlation. For this, 56 daily ice swimmers' data were included in this study. Serum sclerostin and metrnl were measured 30 min before IS and 30 min after. The fat mass, visceral fat area, fat-free mass, skeletal muscle mass, lumbar spine, and femoral neck bone mineral density of the ice swimmers were measured. After IS, sclerostin exhibited significant decreases, whereas metrnl showed no significant change. In addition, the baseline level of sclerostin and the decrease in sclerostin were positively correlated with serum metrnl after adjusting for age, gender, and body composition indicators. IS caused a significant decrease in sclerostin but did not affect metrnl. Furthermore, the associations between sclerostin and metrnl suggested a correlation between osteokines and adipomyokines; this encourages future exploration of the interconnection between bone, muscle, and fat, which will be beneficial for identifying potential common therapeutic targets for diseases such as osteoporosis, sarcopenia, and obesity.
寒冷和运动是影响骨因子和脂肪肌因子分泌的两个重要刺激因素，它们常常同时出现。然而，很少有研究调查过在严寒期间运动诱导的骨因子和脂肪肌因子的变化及其相应关联。因此，本研究旨在调查冷运动（冰泳[IS]）前后硬化蛋白和类流星蛋白（metrnl）的变化，并观察它们之间的相关性。为此，本研究纳入了56名每日进行冰泳者的数据。在冰泳前30分钟和冰泳后30分钟测量血清硬化蛋白和metrnl。测量冰泳者的脂肪量、内脏脂肪面积、去脂体重、骨骼肌质量、腰椎和股骨颈骨密度。冰泳后，硬化蛋白显著降低，而metrnl无显著变化。此外，在调整年龄、性别和身体成分指标后，硬化蛋白的基线水平和硬化蛋白的降低与血清metrnl呈正相关。冰泳导致硬化蛋白显著降低，但不影响metrnl。此外，硬化蛋白和metrnl之间的关联表明骨因子和脂肪肌因子之间存在相关性；这鼓励未来探索骨骼、肌肉和脂肪之间的相互联系，这将有助于确定骨质疏松症、肌肉减少症和肥胖症等疾病潜在的共同治疗靶点。
