Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.
Josep Carreras Leukaemia Research Institute (IJC), 08916 Badalona, Barcelona, Catalonia, Spain.
Trends Mol Med. 2020 Apr;26(4):352-354. doi: 10.1016/j.molmed.2020.01.015. Epub 2020 Feb 18.
In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA-RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a treatment efficacy biomarker. This opens promising avenues of research from both mechanistic and translational perspectives.
在 Fan 等人最近发表在《iScience》上的一篇论文中，长链非编码 RNA（lncRNA）CISAL 被证明能形成 DNA-RNA 三链体，并直接调控 BRCA1 转录，从而增加顺铂敏感性，并作为治疗效果的生物标志物。这为从机制和转化两个角度开展研究开辟了有前景的途径。
