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线粒体 CKMT2 在泛癌中的预后价值及其与肿瘤免疫的相关性分析。

Prognostic value of mitochondrial CKMT2 in Pan-cancer and its tumor immune correlation analysis.

机构信息

State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.

出版信息

Sci Rep. 2024 Jan 3;14(1):342. doi: 10.1038/s41598-023-46468-3.

DOI:10.1038/s41598-023-46468-3
PMID:38172162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10764887/
Abstract

Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine kinase 2 (CKMT2) has been relatively little studied about tumor immunity. We aimed to explore the prognostic value of CKMT2 in 33 cancer types and investigate its potential immune function. We used a range of bioinformatics approaches to explore the potential carcinogenic role of CKMT2 in multiple cancers. CKMT2 was lowly expressed in 14 tumor tissues and highly expressed in 4 tumor tissues. Immunohistochemical assays showed overexpression of CKMT2 in colon cancer and rectal cancer. CKMT2 overexpression was positively correlated with the prognosis of lung adenocarcinoma and prostate cancer. CKMT2 overexpression is mainly enriched in the adaptive immune system and immune regulatory pathways of immunoglobulins. Seven cancers were positively correlated with low CKMT2 expression in tumor microenvironment analysis. Among the five cancers, low expression of CKMT2 resulted in better immunotherapy treatment outcomes. There was a strong correlation between CKMT2 and most immune-related genes in specific cancer types. CKMT2 plays an important role in tumorigenesis and cancer immunity and can be used as a prognostic biomarker and potential target for cancer immunotherapy.

摘要

线粒体代谢被认为在免疫细胞的存活和功能中起着关键作用，但线粒体肌酸激酶 2（CKMT2）在肿瘤免疫方面的研究相对较少。我们旨在探讨 CKMT2 在 33 种癌症类型中的预后价值，并研究其潜在的免疫功能。我们使用了一系列生物信息学方法来探索 CKMT2 在多种癌症中的潜在致癌作用。CKMT2 在 14 种肿瘤组织中低表达，在 4 种肿瘤组织中高表达。免疫组织化学检测显示 CKMT2 在结肠癌和直肠癌中过表达。CKMT2 过表达与肺腺癌和前列腺癌的预后呈正相关。CKMT2 过表达主要富集在适应性免疫系统和免疫球蛋白的免疫调节途径中。肿瘤微环境分析显示，有 7 种癌症与 CKMT2 低表达呈正相关。在这 5 种癌症中，CKMT2 低表达导致更好的免疫治疗效果。CKMT2 与特定癌症类型中的大多数免疫相关基因之间存在很强的相关性。CKMT2 在肿瘤发生和癌症免疫中起着重要作用，可以作为预后生物标志物和癌症免疫治疗的潜在靶点。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/aa26fef135ef/41598_2023_46468_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/c0ebf4abec24/41598_2023_46468_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/364a7410873b/41598_2023_46468_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/0a64202cd691/41598_2023_46468_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/d3f82c24e55b/41598_2023_46468_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e11/10764887/e8bc417283d5/41598_2023_46468_Fig12_HTML.jpg

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