Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, 1215 21st Avenue South, Suite 7209, Nashville, TN 37232-8605, USA.
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, 1215 21st Avenue South, Suite 7209, Nashville, TN 37232-8605, USA.
Immunol Allergy Clin North Am. 2020 May;40(2):281-293. doi: 10.1016/j.iac.2019.12.007. Epub 2020 Jan 14.
Chronic rhinosinusitis (CRS) is a heterogeneous disease process with a complex underlying cause. Improved understanding of CRS pathophysiology has facilitated new approaches to management of the patient with CRS that rely on targeting patient-specific characteristics and individual inflammatory pathways. A more personalized approach to care will ultimately incorporate a combination of phenotypic and endotypic classification systems to guide treatment. This review summarizes current evidence with respect to CRS phenotypes and endotypes, as well as the identification of potential biomarkers with potential to guide current and future treatment algorithms.
慢性鼻-鼻窦炎（CRS）是一种具有复杂潜在病因的异质性疾病过程。对 CRS 病理生理学的深入了解促进了针对 CRS 患者的新管理方法的发展，这些方法依赖于针对患者特异性特征和个体炎症途径。更个性化的护理方法最终将结合表型和内型分类系统的组合来指导治疗。这篇综述总结了目前关于 CRS 表型和内型的证据，以及识别潜在生物标志物的可能性，这些标志物有可能指导当前和未来的治疗算法。
