Fiorentino Vincenzo, Martini Maurizio, Galletti Cosimo, Pizzimenti Cristina, Franchina Mariausilia, Ieni Antonio, Fadda Guido, Galletti Bruno, Tuccari Giovanni
Dipartimento di Patologia Umana Dell'adulto e Dell'età Evolutiva Gaetano Barresi, Università Degli Studi di Messina, 98122 Messina, Italy.
Dipartimento di Scienze Biomediche, Odontoiatriche e Delle Immagini Morfologiche e Funzionali, Università Degli Studi di Messina, 98122 Messina, Italy.
J Pers Med. 2024 Apr 14;14(4):414. doi: 10.3390/jpm14040414.
Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life.
The aim of our study was to evaluate the histological features and inflammatory cellular components of NPs in a retrospective cohort (143 cases) of pediatric, adult and elderly populations in order to discuss the possible morphological age-related differences statistically documented.
In the pediatric group, the inflammatory infiltrate presented many eosinophils mixed with lymphocytes, while in the adult population, lymphocytes and plasma cells were mainly evident, frequently with a perivascular distribution or with the formation of subepithelial lymphoid nodules. In the elderly population, inflammation was less evident and was associated with cavernous-like angecthatic structures with thrombotic stratification. Nearly all morphological findings exhibited statistically significant values among differently aged subgroups.
Our results support the presence of histological specificities of NPs at different ages of life, providing new insight into the etiopathogenesis of NPs. The future role of biological therapies, mainly in cases refractory to already available standard medical and surgical treatments, may be analyzed by a prospective study using a larger cohort with a long-term evaluation also in relation to a possible relapse.
鼻息肉（NPs）是慢性鼻-鼻窦炎（CRS）的终末期表现，CRS是一种在各年龄段都相对常见的病理状况。
我们研究的目的是评估一个包含儿科、成人和老年人群的回顾性队列（143例）中鼻息肉的组织学特征和炎性细胞成分，以便讨论统计学记录的可能存在的与年龄相关的形态学差异。
在儿科组中，炎性浸润表现为许多嗜酸性粒细胞与淋巴细胞混合，而在成人人群中，淋巴细胞和浆细胞主要较为明显，常呈血管周围分布或形成上皮下淋巴小结。在老年人群中，炎症不太明显，且与伴有血栓分层的海绵状血管扩张结构有关。几乎所有形态学结果在不同年龄亚组间均表现出统计学显著差异。
我们的结果支持鼻息肉在生命不同年龄段存在组织学特异性，为鼻息肉的病因发病机制提供了新的见解。生物疗法的未来作用，主要是在对现有标准药物和手术治疗难治的病例中，可能需要通过一项前瞻性研究进行分析，该研究使用更大的队列，并进行长期评估，同时考虑可能的复发情况。
