Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea University, Seoul 02841, Korea.
Int J Mol Sci. 2021 Apr 29;22(9):4744. doi: 10.3390/ijms22094744.
The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.
鼻腔炎症性疾病的发病机制与解剖结构、遗传和环境等多种因素有关。鼻腔微生物群在协调免疫系统功能方面发挥着关键作用。微生物群的功能障碍对鼻腔炎症的发生和发展有重大影响。本综述将介绍涉及慢性鼻窦炎和变应性鼻炎等鼻腔黏膜疾病的免疫相关的微生物群的正反两方面作用。此外，我们还将介绍 DNA 测序、代谢组学和蛋白质组学与基于计算的生物信息学相结合的最新进展。
