Brand Caroline, Gaya Adroaldo Cezar Araujo, Dias Arieli Fernandes, Agostinis-Sobrinho Cesar, Farinha Juliano Boufleur, Boeno Francesco Pinto, Mota Jorge, Reischak de Oliveira Alvaro, Gaya Anelise Reis
School of Physical Education, Physiotherapy and Dance, Post-Graduation Program in Human Movement Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Faculty of Health Sciences, Klaipeda University, Klaipeda, Lithuania.
Ann Hum Biol. 2020 May;47(3):244-249. doi: 10.1080/03014460.2020.1740320. Epub 2020 Apr 13.
Leptin and adiponectin interact with each other in the modulation of obesity and insulin resistance (IR) and it is also important to consider the role of cardiorespiratory and muscular fitness in these relationships.: To analyse the relationship between IR with adipocytokines in children, and to test the mediation effect of %BF (percentage of body fat) in the association of IR with leptin, adiponectin, and L/A ratio. This cross-sectional study comprised a sample of 150 schoolchildren, aged 6-11 years, from school in Porto Alegre, Brazil. The following variables were evaluated: cardiorespiratory fitness (CRF), muscular fitness (MF), percentage of body fat (%BF), and biochemical variables (leptin, adiponectin, glucose, and insulin). IR was associated with leptin and L/A ratio, after adjustments for age, sex, sexual maturation, and CRF. When adjusted for age, sex, sexual maturation, and MF, an association was found between IR with leptin and L/A ratio. Moreover, %BF was a mediator in the association between IR and leptin, as well as IR and L/A ratio, explaining 54% and 57% of these associations, respectively. Leptin and L/A ratio are positively associated with IR after adjustments. Also, %BF is a mediator in the associations between IR and leptin and L/A ratio.
瘦素和脂联素在肥胖和胰岛素抵抗（IR）的调节中相互作用，同时考虑心肺功能和肌肉健康在这些关系中的作用也很重要。：分析儿童IR与脂肪细胞因子之间的关系，并测试体脂百分比（%BF）在IR与瘦素、脂联素及L/A比值关联中的中介作用。这项横断面研究包括来自巴西阿雷格里港一所学校的150名6至11岁学童。评估了以下变量：心肺功能（CRF）、肌肉健康（MF）、体脂百分比（%BF）以及生化变量（瘦素、脂联素、葡萄糖和胰岛素）。在对年龄、性别、性成熟和CRF进行调整后，IR与瘦素和L/A比值相关。在对年龄、性别、性成熟和MF进行调整后，发现IR与瘦素和L/A比值之间存在关联。此外，%BF是IR与瘦素以及IR与L/A比值之间关联的中介，分别解释了这些关联的54%和57%。调整后，瘦素和L/A比值与IR呈正相关。此外，%BF是IR与瘦素和L/A比值之间关联的中介。
