Vestergaard P, Schou M
Department A, Psychiatric Hospital, Risskov, Denmark.
Acta Psychiatr Scand. 1988 Oct;78(4):421-6. doi: 10.1111/j.1600-0447.1988.tb06361.x.
Since 1979, patients started on long-term lithium treatment at the Psychiatric Hospital in Risskov have been followed systematically with recording of clinical and laboratory variables before the start of treatment, after 6 and 12 months of treatment, and thereafter at yearly intervals. By June 1987, 480 examinations had been carried out before the start of lithium treatment, 236 after treatment for 6 months, and decreasing numbers up to 7 years of lithium treatment. The total lithium exposure time was 548 years. The mean lithium dose was 23.2 mmol/d and the mean serum lithium concentration 0.68 mmol/l. These values are about 30% lower than the corresponding values in patients given lithium treatment prior to 1979. About one half of the patients who had gone through the pre-lithium examinations did not reach the 6-month examination. This was because they did not start lithium, or because they stopped it again before 6 months of treatment or before they had reached that point. Thereafter there was a drop-out rate of about 25% per year during the first 2 years of lithium treatment and about 10% per year after 4-5 years of treatment. More men than women left the cohort.
自1979年以来，在里斯科夫精神病院开始接受长期锂治疗的患者，在治疗开始前、治疗6个月和12个月后以及此后每年都对临床和实验室变量进行系统记录。到1987年6月，在锂治疗开始前进行了480次检查，治疗6个月后进行了236次检查，随着锂治疗长达7年，检查次数逐渐减少。锂的总暴露时间为548年。锂的平均剂量为23.2 mmol/d，血清锂平均浓度为0.68 mmol/l。这些值比1979年以前接受锂治疗的患者的相应值低约30%。约一半接受锂治疗前检查的患者未进行6个月检查。这是因为他们没有开始锂治疗，或者因为他们在治疗6个月前或未达到该时间点之前就停止了治疗。此后，在锂治疗的前两年中，每年的退出率约为25%，在治疗4至5年后每年约为10%。离开该队列的男性多于女性。
