Chin Eric M, Gwynn Hilary E, Robinson Shenandoah, Hoon Alexander H
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA.
Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA.
Neurol Clin. 2020 May;38(2):397-416. doi: 10.1016/j.ncl.2020.01.009.
Cerebral palsy is the most common cause of childhood motor disability, affecting 2 to 3/1000 children worldwide. Clinical abnormalities in tone, posture, and movement are the result of brain dysgenesis or injury early in life, and impairment varies in type, distribution, and in severity. The underlying brain disorder may also lead to other associated neurologic and systemic impairments. Variability in functional impairments, which can change during development, necessitates an individualized treatment plan. Treatment options are primarily symptomatic and directed toward optimizing independence, function, and/or ease of care-while limiting side effects. New promising disease-preventing and modifying treatments are emerging.
脑瘫是儿童运动残疾最常见的病因,全球每1000名儿童中有2至3名受其影响。肌张力、姿势和运动方面的临床异常是生命早期脑发育异常或损伤的结果,其损害在类型、分布和严重程度上各不相同。潜在的脑部疾病还可能导致其他相关的神经和全身损害。功能损害的变异性在发育过程中可能会发生变化,因此需要个性化的治疗方案。治疗选择主要是对症治疗,旨在优化独立性、功能和/或护理的便利性,同时限制副作用。新的有前景的疾病预防和改善治疗方法正在出现。