Santilli Anthony D, Russell Jordan T, Triplett Eric W, Whitehead Kristi J, Whitehead Daniel C
Department of Chemistry , Clemson University , Clemson , SC 29631 , USA . Email:
Department of Microbiology and Cell Science , University of Florida , Gainesville , FL 32611 , USA.
Medchemcomm. 2019 Jul 5;10(11):1875-1880. doi: 10.1039/c9md00301k. eCollection 2019 Nov 1.
We describe the inhibition of the starch utilization system (Sus) belonging to various strains of in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of and increase the doubling time of cultures. The successful inhibition of this species of is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents.
我们描述了使用小分子探针阿卡波糖以非致死方式抑制属于各种菌株的淀粉利用系统（Sus）。低至5μM的阿卡波糖浓度会显著阻碍菌株的生长并延长培养物的倍增时间。成功抑制这种菌株与包括I型糖尿病在内的几种疾病状态相关。该方法继续探索一条新的潜在途径，即通过对人类肠道微生物群组成成分的策略性操纵来干预与肠道微生物群异常变化相关的疾病。
