• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗性淀粉对冠心病患者肠道微生物群及其代谢物的影响。

Effect of Resistant Starch on the Gut Microbiota and Its Metabolites in Patients with Coronary Artery Disease.

机构信息

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine.

Graduate School of Science, Technology and Innovation, Kobe University.

出版信息

J Atheroscler Thromb. 2019 Aug 1;26(8):705-719. doi: 10.5551/jat.47415. Epub 2018 Dec 27.

DOI:10.5551/jat.47415
PMID:30587666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6711844/
Abstract

AIM

Bacteroides vulgatus and B. dorei have a protective effect against atherosclerosis, suggesting that expansion of these species in the gut microbiota could help patients with coronary artery disease (CAD). This study aimed to investigate the effect of resistant starch (RS) on the gut microbiota and its metabolites in fecal sample cultures from patients with CAD and individuals without CAD, using a single-batch fermentation system.

METHODS

Fecal samples from 11 patients with CAD and 10 individuals without CAD were fermented for 30 h with or without RS in the Kobe University Human Intestinal Microbiota Model (KUHIMM). Gut microbiota and the abundance of B. vulgatus and B. dorei were analyzed using 16S ribosomal ribonucleic acid (rRNA) gene sequencing and the quantitative polymerase chain reaction. Short-chain fatty acids were analyzed using high-performance liquid chromatography.

RESULTS

Gut microbial analysis showed significantly lower levels of B. vulgatus and B. dorei in the original fecal samples from patients with CAD, which was simulated after 30 h of fermentation in the KUHIMM. Although RS significantly increased the absolute numbers of B. vulgatus and B. dorei, and butyrate levels in CAD fecal sample cultures, the numbers varied among each patient.

CONCLUSIONS

The effect of RS on gut microbiota and its metabolites in the KUHIMM varied between CAD and non-CAD fecal sample cultures. The KUHIMM may be useful for preclinical evaluations of the effects of RS on the gut microbiota and its metabolites.

摘要

目的

脆弱拟杆菌和多形拟杆菌对动脉粥样硬化具有保护作用，这表明这些物种在肠道微生物群中的扩张可能有助于冠心病（CAD）患者。本研究旨在使用单批次发酵系统，研究抗性淀粉（RS）对 CAD 患者和无 CAD 个体粪便样本培养物中的肠道微生物群及其代谢物的影响。

方法

用或不用 RS 将来自 11 名 CAD 患者和 10 名无 CAD 个体的粪便样本在神户大学人类肠道微生物群模型（KUHIMM）中发酵 30 小时。使用 16S 核糖体核糖核酸（rRNA）基因测序和定量聚合酶链反应分析肠道微生物群和脆弱拟杆菌和多形拟杆菌的丰度。使用高效液相色谱法分析短链脂肪酸。

结果

肠道微生物分析显示，CAD 患者原始粪便样本中的脆弱拟杆菌和多形拟杆菌水平明显较低，在 KUHIMM 中发酵 30 小时后可模拟出这一结果。虽然 RS 显著增加了 CAD 粪便样本培养物中脆弱拟杆菌和多形拟杆菌的绝对数量和丁酸盐水平，但每个患者的数量都有所不同。

结论

RS 对 KUHIMM 中 CAD 和非 CAD 粪便样本培养物中肠道微生物群及其代谢物的影响不同。KUHIMM 可能有助于 RS 对肠道微生物群及其代谢物影响的临床前评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/fbb5f383a6c2/jat-26-705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/e50c59c37878/jat-26-705-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/56a6f14c817a/jat-26-705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/5b4ea4bfa44f/jat-26-705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/24292c947474/jat-26-705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/02620b4fbb0a/jat-26-705-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/42fb80927a9d/jat-26-705-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/a50a1f993db0/jat-26-705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/fbb5f383a6c2/jat-26-705-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/e50c59c37878/jat-26-705-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/56a6f14c817a/jat-26-705-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/5b4ea4bfa44f/jat-26-705-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/24292c947474/jat-26-705-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/02620b4fbb0a/jat-26-705-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/42fb80927a9d/jat-26-705-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/a50a1f993db0/jat-26-705-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/752f/6711844/fbb5f383a6c2/jat-26-705-g004.jpg

相似文献

1
Effect of Resistant Starch on the Gut Microbiota and Its Metabolites in Patients with Coronary Artery Disease.抗性淀粉对冠心病患者肠道微生物群及其代谢物的影响。
J Atheroscler Thromb. 2019 Aug 1;26(8):705-719. doi: 10.5551/jat.47415. Epub 2018 Dec 27.
2
Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis.脆弱拟杆菌和多形拟杆菌减少肠道微生物脂多糖的产生并抑制动脉粥样硬化。
Circulation. 2018 Nov 27;138(22):2486-2498. doi: 10.1161/CIRCULATIONAHA.118.033714.
3
Variable responses of human microbiomes to dietary supplementation with resistant starch.膳食纤维补充物对人体微生物组的可变响应。
Microbiome. 2016 Jun 29;4(1):33. doi: 10.1186/s40168-016-0178-x.
4
Gut microbial features and dietary fiber intake predict gut microbiota response to resistant starch supplementation.肠道微生物特征和膳食纤维摄入量可预测肠道微生物群对抗性淀粉补充的反应。
Gut Microbes. 2024 Jan-Dec;16(1):2367301. doi: 10.1080/19490976.2024.2367301. Epub 2024 Jun 24.
5
Dysbiosis signatures of gut microbiota in coronary artery disease.肠道微生物失调特征与冠状动脉疾病。
Physiol Genomics. 2018 Oct 1;50(10):893-903. doi: 10.1152/physiolgenomics.00070.2018. Epub 2018 Sep 7.
6
Characterization of fecal fat composition and gut derived fecal microbiota in high-fat diet fed rats following intervention with chito-oligosaccharide and resistant starch complexes.高脂肪饮食喂养的大鼠经壳寡糖和抗性淀粉复合物干预后粪便脂肪成分和肠道来源粪便微生物群的特征。
Food Funct. 2017 Dec 13;8(12):4374-4383. doi: 10.1039/c7fo01244f.
7
Alterations in the gut microbiome and metabolism with coronary artery disease severity.肠道微生物组和代谢与冠状动脉疾病严重程度的改变。
Microbiome. 2019 Apr 26;7(1):68. doi: 10.1186/s40168-019-0683-9.
8
Effects of Lactic Acid Bacteria-Fermented Soymilk on Isoflavone Metabolites and Short-Chain Fatty Acids Excretion and Their Modulating Effects on Gut Microbiota.乳酸菌发酵豆浆对异黄酮代谢物和短链脂肪酸排泄的影响及其对肠道微生物群的调节作用。
J Food Sci. 2019 Jul;84(7):1854-1863. doi: 10.1111/1750-3841.14661. Epub 2019 Jun 17.
9
Impact of Dietary Resistant Starch on the Human Gut Microbiome, Metaproteome, and Metabolome.膳食抗性淀粉对人类肠道微生物组、宏蛋白质组和代谢组的影响。
mBio. 2017 Oct 17;8(5):e01343-17. doi: 10.1128/mBio.01343-17.
10
Fecal metabonomics combined with 16S rRNA gene sequencing to analyze the changes of gut microbiota in rats with kidney-yang deficiency syndrome and the intervention effect of You-gui pill.基于粪便代谢组学联合 16S rRNA 基因测序分析肾阳虚证大鼠肠道菌群变化及右归丸的干预作用
J Ethnopharmacol. 2019 Nov 15;244:112139. doi: 10.1016/j.jep.2019.112139. Epub 2019 Aug 8.

引用本文的文献

1
Intestinal microbiome as a diagnostic marker of coronary artery disease: a systematic review and meta-analysis.肠道微生物群作为冠状动脉疾病的诊断标志物：一项系统评价和荟萃分析。
Ann Med Surg (Lond). 2024 Sep 4;86(10):6105-6120. doi: 10.1097/MS9.0000000000002516. eCollection 2024 Oct.
2
Impact of a Fruit-Vegetable Preparation Fortified with Potato Starch Resistant Dextrin on Selected Health Indicators in Overweight Children.富含马铃薯抗性糊精的果蔬制剂对超重儿童部分健康指标的影响。
Nutrients. 2024 Jul 18;16(14):2321. doi: 10.3390/nu16142321.
3
Insights from metagenomics into gut microbiome associated with acute coronary syndrome therapy.

本文引用的文献

1
Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis.脆弱拟杆菌和多形拟杆菌减少肠道微生物脂多糖的产生并抑制动脉粥样硬化。
Circulation. 2018 Nov 27;138(22):2486-2498. doi: 10.1161/CIRCULATIONAHA.118.033714.
2
Gut Microbiome and Cardiovascular Diseases.肠道微生物群与心血管疾病
Diseases. 2018 Jun 29;6(3):56. doi: 10.3390/diseases6030056.
3
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes.膳食纤维选择性促进肠道细菌，可缓解 2 型糖尿病。
宏基因组学对急性冠状动脉综合征治疗相关肠道微生物群的见解。
Front Microbiol. 2024 Jul 5;15:1369478. doi: 10.3389/fmicb.2024.1369478. eCollection 2024.
4
A Comprehensive Pilot Study to Elucidate the Distinct Gut Microbial Composition and Its Functional Significance in Cardio-Metabolic Disease.一项全面的试点研究，旨在阐明心血管代谢疾病中独特的肠道微生物组成及其功能意义。
Biochem Genet. 2025 Jun;63(3):2716-2742. doi: 10.1007/s10528-024-10847-w. Epub 2024 Jun 5.
5
Establishment of porcine fecal-derived microbial communities to evaluate the impact of livestock feed on gut microbiome.建立猪粪便来源的微生物群落以评估家畜饲料对肠道微生物组的影响。
Biosci Microbiota Food Health. 2024;43(2):100-109. doi: 10.12938/bmfh.2023-085. Epub 2023 Nov 15.
6
Different Starch Sources Affect the Growth Performance and Hepatic Health Status of Largemouth Bass () in a High-Temperature Environment.不同淀粉来源对高温环境下大口黑鲈生长性能和肝脏健康状况的影响
Animals (Basel). 2023 Dec 10;13(24):3808. doi: 10.3390/ani13243808.
7
Sulfated and non-sulfated chondroitin affect the composition and metabolism of human colonic microbiota simulated in an in vitro fermentation system.硫酸化和非硫酸化的软骨素会影响体外发酵系统中模拟的人类结肠微生物群的组成和代谢。
Sci Rep. 2023 Jul 29;13(1):12313. doi: 10.1038/s41598-023-38849-5.
8
Stilbene-based derivatives as potential inhibitors of trimethylamine (TMA)-lyase affect gut microbiota in coronary heart disease.基于芪的衍生物作为三甲胺（TMA）裂解酶的潜在抑制剂对冠心病患者肠道微生物群的影响
Food Sci Nutr. 2022 Sep 12;11(1):93-100. doi: 10.1002/fsn3.3046. eCollection 2023 Jan.
9
Human Gut Microbiota in Coronary Artery Disease: A Systematic Review and Meta-Analysis.冠状动脉疾病中的人类肠道微生物群：一项系统评价和荟萃分析。
Metabolites. 2022 Nov 23;12(12):1165. doi: 10.3390/metabo12121165.
10
A Novel Immunobiotics Ameliorates Influenza Virus Infection in Mice.新型免疫生物制剂改善小鼠流感病毒感染
Front Immunol. 2022 Jan 26;12:828887. doi: 10.3389/fimmu.2021.828887. eCollection 2021.
Science. 2018 Mar 9;359(6380):1151-1156. doi: 10.1126/science.aao5774.
4
In Vivo Assessment of Resistant Starch Degradation by the Caecal Microbiota of Mice Using RNA-Based Stable Isotope Probing-A Proof-of-Principle Study.利用基于 RNA 的稳定同位素探测技术评估肠道微生物群对抗性淀粉的降解：一项原理验证研究。
Nutrients. 2018 Feb 6;10(2):179. doi: 10.3390/nu10020179.
5
Low amounts of dietary fibre increase in vitro production of short-chain fatty acids without changing human colonic microbiota structure.低膳食纤维摄入量可增加短链脂肪酸的体外产量，而不改变人类结肠微生物群结构。
Sci Rep. 2018 Jan 11;8(1):435. doi: 10.1038/s41598-017-18877-8.
6
The gut microbiome in atherosclerotic cardiovascular disease.动脉粥样硬化性心血管疾病中的肠道微生物群
Nat Commun. 2017 Oct 10;8(1):845. doi: 10.1038/s41467-017-00900-1.
7
Taurine does not affect the composition, diversity, or metabolism of human colonic microbiota simulated in a single-batch fermentation system.牛磺酸不影响在单批次发酵系统中模拟的人类结肠微生物群的组成、多样性或代谢。
PLoS One. 2017 Jul 10;12(7):e0180991. doi: 10.1371/journal.pone.0180991. eCollection 2017.
8
Dietary fibre in Europe: current state of knowledge on definitions, sources, recommendations, intakes and relationships to health.欧洲的膳食纤维：定义、来源、推荐量、摄入量和与健康关系的现有知识状况。
Nutr Res Rev. 2017 Dec;30(2):149-190. doi: 10.1017/S095442241700004X. Epub 2017 Jul 5.
9
Are Short Chain Fatty Acids in Gut Microbiota Defensive Players for Inflammation and Atherosclerosis?肠道微生物群中的短链脂肪酸是炎症和动脉粥样硬化的防御者吗？
J Atheroscler Thromb. 2017 Jul 1;24(7):660-672. doi: 10.5551/jat.RV17006. Epub 2017 May 27.
10
Impact of Lipoprotein (a) on Long-Term Outcomes in Patients with Coronary Artery Disease Treated with Statin After a First Percutaneous Coronary Intervention.脂蛋白（a）对首次经皮冠状动脉介入治疗后接受他汀类药物治疗的冠心病患者长期结局的影响。
J Atheroscler Thromb. 2017 Nov 1;24(11):1125-1131. doi: 10.5551/jat.38794. Epub 2017 Mar 17.